Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep

Abstract Anthelmintic treatment of adult ewes is widely practiced to remove parasite burdens in the expectation of increased ruminant productivity. However, the broad activity spectra of many anthelmintic compounds raises the possibility of impacts on the rumen microbiota. To investigate this, 300 g...

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Autores principales:	Christina D. Moon, Luis Carvalho, Michelle R. Kirk, Alan F. McCulloch, Sandra Kittelmann, Wayne Young, Peter H. Janssen, Dave M. Leathwick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04061fa5a4994f75aa7613e71c3053ad
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spelling	oai:doaj.org-article:04061fa5a4994f75aa7613e71c3053ad2021-12-02T14:03:46ZEffects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep10.1038/s41598-021-82815-y2045-2322https://doaj.org/article/04061fa5a4994f75aa7613e71c3053ad2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82815-yhttps://doaj.org/toc/2045-2322Abstract Anthelmintic treatment of adult ewes is widely practiced to remove parasite burdens in the expectation of increased ruminant productivity. However, the broad activity spectra of many anthelmintic compounds raises the possibility of impacts on the rumen microbiota. To investigate this, 300 grazing ewes were allocated to treatment groups that included a 100-day controlled release capsule (CRC) containing albendazole and abamectin, a long-acting moxidectin injection (LAI), and a non-treated control group (CON). Rumen bacterial, archaeal and protozoal communities at day 0 were analysed to identify 36 sheep per treatment with similar starting compositions. Microbiota profiles, including those for the rumen fungi, were then generated for the selected sheep at days 0, 35 and 77. The CRC treatment significantly impacted the archaeal community, and was associated with increased relative abundances of Methanobrevibacter ruminantium, Methanosphaera sp. ISO3-F5, and Methanomassiliicoccaceae Group 12 sp. ISO4-H5 compared to the control group. In contrast, the LAI treatment increased the relative abundances of members of the Veillonellaceae and resulted in minor changes to the bacterial and fungal communities by day 77. Overall, the anthelmintic treatments resulted in few, but highly significant, changes to the rumen microbiota composition.Christina D. MoonLuis CarvalhoMichelle R. KirkAlan F. McCullochSandra KittelmannWayne YoungPeter H. JanssenDave M. LeathwickNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christina D. Moon Luis Carvalho Michelle R. Kirk Alan F. McCulloch Sandra Kittelmann Wayne Young Peter H. Janssen Dave M. Leathwick Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
description	Abstract Anthelmintic treatment of adult ewes is widely practiced to remove parasite burdens in the expectation of increased ruminant productivity. However, the broad activity spectra of many anthelmintic compounds raises the possibility of impacts on the rumen microbiota. To investigate this, 300 grazing ewes were allocated to treatment groups that included a 100-day controlled release capsule (CRC) containing albendazole and abamectin, a long-acting moxidectin injection (LAI), and a non-treated control group (CON). Rumen bacterial, archaeal and protozoal communities at day 0 were analysed to identify 36 sheep per treatment with similar starting compositions. Microbiota profiles, including those for the rumen fungi, were then generated for the selected sheep at days 0, 35 and 77. The CRC treatment significantly impacted the archaeal community, and was associated with increased relative abundances of Methanobrevibacter ruminantium, Methanosphaera sp. ISO3-F5, and Methanomassiliicoccaceae Group 12 sp. ISO4-H5 compared to the control group. In contrast, the LAI treatment increased the relative abundances of members of the Veillonellaceae and resulted in minor changes to the bacterial and fungal communities by day 77. Overall, the anthelmintic treatments resulted in few, but highly significant, changes to the rumen microbiota composition.
format	article
author	Christina D. Moon Luis Carvalho Michelle R. Kirk Alan F. McCulloch Sandra Kittelmann Wayne Young Peter H. Janssen Dave M. Leathwick
author_facet	Christina D. Moon Luis Carvalho Michelle R. Kirk Alan F. McCulloch Sandra Kittelmann Wayne Young Peter H. Janssen Dave M. Leathwick
author_sort	Christina D. Moon
title	Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
title_short	Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
title_full	Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
title_fullStr	Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
title_full_unstemmed	Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
title_sort	effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04061fa5a4994f75aa7613e71c3053ad
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Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep

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