Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study

Hypertension has been reported as a major risk factor for diseases such as cardiovascular disease, and associations between platelet activation and risk for hypertension are well-established. However, the exact nature of causality between them remains unclear. In this study, a bi-directional Mendeli...

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Autores principales:	Po-Chun Chiu, Amrita Chattopadhyay, Meng-Chun Wu, Tzu-Hung Hsiao, Ching-Heng Lin, Tzu-Pin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Mendelian randomization bi-directional causal estimation hypertension platelet count Taiwan Biobank Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/04074e4078834feaa0c38fadd2d0c441
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spelling	oai:doaj.org-article:04074e4078834feaa0c38fadd2d0c4412021-12-01T05:43:43ZElucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study2297-055X10.3389/fcvm.2021.743075https://doaj.org/article/04074e4078834feaa0c38fadd2d0c4412021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.743075/fullhttps://doaj.org/toc/2297-055XHypertension has been reported as a major risk factor for diseases such as cardiovascular disease, and associations between platelet activation and risk for hypertension are well-established. However, the exact nature of causality between them remains unclear. In this study, a bi-directional Mendelian randomization (MR) analysis was conducted on 15,996 healthy Taiwanese individuals aged between 30 and 70 years from the Taiwan Biobank, recorded between 2008 and 2015. The inverse variance weighted (IVW) method was applied to determine the causal relationship between platelet count and hypertension with single nucleotide polymorphisms as instrumental variables (IVs). Furthermore, to check for pleiotropy and validity of the IVs, sensitivity analyses were performed using the MR-Egger, weighted median and simple median methods. This study provided evidence in support of a positive causal effect of platelet count on the risk of hypertension (odds ratio: 1.149, 95% confidence interval: 1.131–1.578, P < 0.05), using the weighted median method. A significant causal effect of platelet count on hypertension was observed using the IVW method. No pleiotropy was observed. The causal effect of hypertension on platelet count was found to be non-significant. Therefore, the findings from this study provide evidence that higher platelet count may have a significant causal effect on the elevated risk of hypertension for the general population of Taiwan.Po-Chun ChiuAmrita ChattopadhyayMeng-Chun WuTzu-Hung HsiaoChing-Heng LinTzu-Pin LuTzu-Pin LuTzu-Pin LuFrontiers Media S.A.articleMendelian randomizationbi-directional causal estimationhypertensionplatelet countTaiwan BiobankDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mendelian randomization bi-directional causal estimation hypertension platelet count Taiwan Biobank Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Mendelian randomization bi-directional causal estimation hypertension platelet count Taiwan Biobank Diseases of the circulatory (Cardiovascular) system RC666-701 Po-Chun Chiu Amrita Chattopadhyay Meng-Chun Wu Tzu-Hung Hsiao Ching-Heng Lin Tzu-Pin Lu Tzu-Pin Lu Tzu-Pin Lu Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
description	Hypertension has been reported as a major risk factor for diseases such as cardiovascular disease, and associations between platelet activation and risk for hypertension are well-established. However, the exact nature of causality between them remains unclear. In this study, a bi-directional Mendelian randomization (MR) analysis was conducted on 15,996 healthy Taiwanese individuals aged between 30 and 70 years from the Taiwan Biobank, recorded between 2008 and 2015. The inverse variance weighted (IVW) method was applied to determine the causal relationship between platelet count and hypertension with single nucleotide polymorphisms as instrumental variables (IVs). Furthermore, to check for pleiotropy and validity of the IVs, sensitivity analyses were performed using the MR-Egger, weighted median and simple median methods. This study provided evidence in support of a positive causal effect of platelet count on the risk of hypertension (odds ratio: 1.149, 95% confidence interval: 1.131–1.578, P < 0.05), using the weighted median method. A significant causal effect of platelet count on hypertension was observed using the IVW method. No pleiotropy was observed. The causal effect of hypertension on platelet count was found to be non-significant. Therefore, the findings from this study provide evidence that higher platelet count may have a significant causal effect on the elevated risk of hypertension for the general population of Taiwan.
format	article
author	Po-Chun Chiu Amrita Chattopadhyay Meng-Chun Wu Tzu-Hung Hsiao Ching-Heng Lin Tzu-Pin Lu Tzu-Pin Lu Tzu-Pin Lu
author_facet	Po-Chun Chiu Amrita Chattopadhyay Meng-Chun Wu Tzu-Hung Hsiao Ching-Heng Lin Tzu-Pin Lu Tzu-Pin Lu Tzu-Pin Lu
author_sort	Po-Chun Chiu
title	Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
title_short	Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
title_full	Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
title_fullStr	Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
title_full_unstemmed	Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study
title_sort	elucidation of a causal relationship between platelet count and hypertension: a bi-directional mendelian randomization study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/04074e4078834feaa0c38fadd2d0c441
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Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study

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