Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder

BackgroundPrimary neuroendocrine tumors of the gallbladder (GB-NETs) are rare, accounting for 2% of all gallbladder cancers. Among GB-NETs, mixed neuroendocrine non-neuroendocrine neoplasms of the gallbladder (GB-MiNENs) are sporadic.Case PresentationA 56-year-old woman admitted to our hospital due...

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Autores principales:	Chao Liu, Xiangwei Hua, Zhen Yang, Yuan Guo, Liqun Wu, Jinzhen Cai, Ling Li, Yaxuan Zhang, Ning Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	case report MiNENs a PD-1 inhibitor sintilimab gallbladder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0407c508935e45e282507bc7540673ad
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spelling	oai:doaj.org-article:0407c508935e45e282507bc7540673ad2021-11-18T09:01:34ZCase Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder2234-943X10.3389/fonc.2021.770156https://doaj.org/article/0407c508935e45e282507bc7540673ad2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.770156/fullhttps://doaj.org/toc/2234-943XBackgroundPrimary neuroendocrine tumors of the gallbladder (GB-NETs) are rare, accounting for 2% of all gallbladder cancers. Among GB-NETs, mixed neuroendocrine non-neuroendocrine neoplasms of the gallbladder (GB-MiNENs) are sporadic.Case PresentationA 56-year-old woman admitted to our hospital due to right upper abdominal pain of 3 days duration. She underwent positron emission tomography/computed tomography, which showed multiple metastatic tumors and was unsuitable for operation. Initially, the patient was diagnosed with gallbladder adenocarcinoma. She underwent PD-1 inhibitor or combined with chemotherapy considering the PD-L1 high positive score. In the latter, the patient has the opportunity of surgery, and the new diagnosis was MiNENs. She achieved long-term disease control and has been alive from the first diagnosis.ConclusionThis case might support the strategy that PD-1 inhibitor could provide a feasible treatment option for MiNENs of gallbladder patients with the positive expression of PD-L1 in the future.Chao LiuXiangwei HuaZhen YangYuan GuoLiqun WuJinzhen CaiLing LiYaxuan ZhangNing FanFrontiers Media S.A.articlecase reportMiNENsa PD-1 inhibitorsintilimabgallbladderNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	case report MiNENs a PD-1 inhibitor sintilimab gallbladder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	case report MiNENs a PD-1 inhibitor sintilimab gallbladder Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Chao Liu Xiangwei Hua Zhen Yang Yuan Guo Liqun Wu Jinzhen Cai Ling Li Yaxuan Zhang Ning Fan Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
description	BackgroundPrimary neuroendocrine tumors of the gallbladder (GB-NETs) are rare, accounting for 2% of all gallbladder cancers. Among GB-NETs, mixed neuroendocrine non-neuroendocrine neoplasms of the gallbladder (GB-MiNENs) are sporadic.Case PresentationA 56-year-old woman admitted to our hospital due to right upper abdominal pain of 3 days duration. She underwent positron emission tomography/computed tomography, which showed multiple metastatic tumors and was unsuitable for operation. Initially, the patient was diagnosed with gallbladder adenocarcinoma. She underwent PD-1 inhibitor or combined with chemotherapy considering the PD-L1 high positive score. In the latter, the patient has the opportunity of surgery, and the new diagnosis was MiNENs. She achieved long-term disease control and has been alive from the first diagnosis.ConclusionThis case might support the strategy that PD-1 inhibitor could provide a feasible treatment option for MiNENs of gallbladder patients with the positive expression of PD-L1 in the future.
format	article
author	Chao Liu Xiangwei Hua Zhen Yang Yuan Guo Liqun Wu Jinzhen Cai Ling Li Yaxuan Zhang Ning Fan
author_facet	Chao Liu Xiangwei Hua Zhen Yang Yuan Guo Liqun Wu Jinzhen Cai Ling Li Yaxuan Zhang Ning Fan
author_sort	Chao Liu
title	Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
title_short	Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
title_full	Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
title_fullStr	Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
title_full_unstemmed	Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder
title_sort	case report: response with immunotherapy in a patient with mixed neuroendocrine non-neuroendocrine neoplasms of the gallbladder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0407c508935e45e282507bc7540673ad
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Case Report: Response With Immunotherapy in a Patient With Mixed Neuroendocrine Non-Neuroendocrine Neoplasms of the Gallbladder

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