Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.

It has been known for decades that some insect-infecting trypanosomatids can survive in culture without heme supplementation while others cannot, and that this capability is associated with the presence of a betaproteobacterial endosymbiont in the flagellate's cytoplasm. However, the specific m...

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Autores principales:	João M P Alves, Logan Voegtly, Andrey V Matveyev, Ana M Lara, Flávia Maia da Silva, Myrna G Serrano, Gregory A Buck, Marta M G Teixeira, Erney P Camargo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04085939708e41d0af54a7c9f7372c78
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spelling	oai:doaj.org-article:04085939708e41d0af54a7c9f7372c782021-11-18T06:48:16ZIdentification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.1932-620310.1371/journal.pone.0023518https://doaj.org/article/04085939708e41d0af54a7c9f7372c782011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21853145/?tool=EBIhttps://doaj.org/toc/1932-6203It has been known for decades that some insect-infecting trypanosomatids can survive in culture without heme supplementation while others cannot, and that this capability is associated with the presence of a betaproteobacterial endosymbiont in the flagellate's cytoplasm. However, the specific mechanisms involved in this process remained obscure. In this work, we sequence and phylogenetically analyze the heme pathway genes from the symbionts and from their hosts, as well as from a number of heme synthesis-deficient Kinetoplastida. Our results show that the enzymes responsible for synthesis of heme are encoded on the symbiont genomes and produced in close cooperation with the flagellate host. Our evidence suggests that this synergistic relationship is the end result of a history of extensive gene loss and multiple lateral gene transfer events in different branches of the phylogeny of the Trypanosomatidae.João M P AlvesLogan VoegtlyAndrey V MatveyevAna M LaraFlávia Maia da SilvaMyrna G SerranoGregory A BuckMarta M G TeixeiraErney P CamargoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23518 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João M P Alves Logan Voegtly Andrey V Matveyev Ana M Lara Flávia Maia da Silva Myrna G Serrano Gregory A Buck Marta M G Teixeira Erney P Camargo Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
description	It has been known for decades that some insect-infecting trypanosomatids can survive in culture without heme supplementation while others cannot, and that this capability is associated with the presence of a betaproteobacterial endosymbiont in the flagellate's cytoplasm. However, the specific mechanisms involved in this process remained obscure. In this work, we sequence and phylogenetically analyze the heme pathway genes from the symbionts and from their hosts, as well as from a number of heme synthesis-deficient Kinetoplastida. Our results show that the enzymes responsible for synthesis of heme are encoded on the symbiont genomes and produced in close cooperation with the flagellate host. Our evidence suggests that this synergistic relationship is the end result of a history of extensive gene loss and multiple lateral gene transfer events in different branches of the phylogeny of the Trypanosomatidae.
format	article
author	João M P Alves Logan Voegtly Andrey V Matveyev Ana M Lara Flávia Maia da Silva Myrna G Serrano Gregory A Buck Marta M G Teixeira Erney P Camargo
author_facet	João M P Alves Logan Voegtly Andrey V Matveyev Ana M Lara Flávia Maia da Silva Myrna G Serrano Gregory A Buck Marta M G Teixeira Erney P Camargo
author_sort	João M P Alves
title	Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
title_short	Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
title_full	Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
title_fullStr	Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
title_full_unstemmed	Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
title_sort	identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/04085939708e41d0af54a7c9f7372c78
work_keys_str_mv	AT joaompalves identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT loganvoegtly identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT andreyvmatveyev identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT anamlara identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT flaviamaiadasilva identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT myrnagserrano identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT gregoryabuck identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT martamgteixeira identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts AT erneypcamargo identificationandphylogeneticanalysisofhemesynthesisgenesintrypanosomatidsandtheirbacterialendosymbionts
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Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts.

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