Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus

Yan Chen, Ying Zhao, Yanjun Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130041, People’s Republic of ChinaCorrespondence: Yanjun Wang Email jdeywyj@sina.comBackground: Diabetes is a complex metabolic disorder known to induce a high blood gluc...

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Autores principales:	Chen Y, Zhao Y, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	blood glucose dielectric sensor biosensor nanomaterial nanoparticle Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/040a269650fc482198b767ac73ad19ed
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spelling	oai:doaj.org-article:040a269650fc482198b767ac73ad19ed2021-12-02T12:58:50ZFly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus1178-2013https://doaj.org/article/040a269650fc482198b767ac73ad19ed2020-09-01T00:00:00Zhttps://www.dovepress.com/fly-ash-based-zeolite-complexed-polyethylene-glycol-on-an-interdigitat-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yan Chen, Ying Zhao, Yanjun Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130041, People’s Republic of ChinaCorrespondence: Yanjun Wang Email jdeywyj@sina.comBackground: Diabetes is a complex metabolic disorder known to induce a high blood glucose level that fluctuates outside the normal range. Diabetes affects and damages the organs in the body and causes heart issues, blindness and kidney failure. Continuous monitoring is mandatory to keep the blood glucose level within a healthy range.Materials and Methods: This research was focused on diagnosing diabetes mellitus on zeolite nanoparticle-polyethylene glycol complex-immobilized interdigitated electrode sensor (IDE) surfaces. Zeolite nanoparticles were extracted from the fly ash of a thermal power plant by alkaline extraction. The surface morphology of the synthesized nanoparticles was observed by field-emission scanning electron microscopy and transmission electron microscopy, and the presence of certain elements and the particle size were determined by energy-dispersive X-ray spectroscopy and particle size analysis, respectively.Results: The crystalline PEG-zeolite nanoparticles were synthesized with a size of 40± 10 nm according to high-resolution microscopy. A particle size analyzer revealed the sizes of the fly ash and PEG-zeolite particles as 60± 10 μm and 50± 10 nm, respectively. The IDE surface was evaluated for its ability to display antifouling properties and sense glucose levels on the abovementioned nanoparticle-modified surface. Glucose oxidase was probed on the PEG-zeolite-modified IDE surface, and glucose was detected. PEG zeolite performed well with excellent antifouling properties on the IDE sensor surface and improved the glucose detection limit to 0.03 mg/mL from 0.08 mg/mL, as determined by linear regressions [y = 5.365x - 6.803; R2 = 0.9035 (zeolite surface) and y = 5.498x + 5.914R2 = 0.9061 (PEG-zeolite surface)]. This enhancement was &sim; 3-fold, and sensitivities were found to be 0.03 and 0.06 mg/mL glucose for the PEG-zeolite- and zeolite-modified surfaces, respectively, showing a 2-fold difference.Conclusion: The excellent biocompatible surface modified by PEG zeolite exhibited high performance and is useful for medical diagnosis.Keywords: blood glucose, dielectric sensor, biosensor, nanomaterial, nanoparticleChen YZhao YWang YDove Medical Pressarticleblood glucosedielectric sensorbiosensornanomaterialnanoparticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6619-6629 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood glucose dielectric sensor biosensor nanomaterial nanoparticle Medicine (General) R5-920
spellingShingle	blood glucose dielectric sensor biosensor nanomaterial nanoparticle Medicine (General) R5-920 Chen Y Zhao Y Wang Y Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
description	Yan Chen, Ying Zhao, Yanjun Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, Jilin 130041, People’s Republic of ChinaCorrespondence: Yanjun Wang Email jdeywyj@sina.comBackground: Diabetes is a complex metabolic disorder known to induce a high blood glucose level that fluctuates outside the normal range. Diabetes affects and damages the organs in the body and causes heart issues, blindness and kidney failure. Continuous monitoring is mandatory to keep the blood glucose level within a healthy range.Materials and Methods: This research was focused on diagnosing diabetes mellitus on zeolite nanoparticle-polyethylene glycol complex-immobilized interdigitated electrode sensor (IDE) surfaces. Zeolite nanoparticles were extracted from the fly ash of a thermal power plant by alkaline extraction. The surface morphology of the synthesized nanoparticles was observed by field-emission scanning electron microscopy and transmission electron microscopy, and the presence of certain elements and the particle size were determined by energy-dispersive X-ray spectroscopy and particle size analysis, respectively.Results: The crystalline PEG-zeolite nanoparticles were synthesized with a size of 40± 10 nm according to high-resolution microscopy. A particle size analyzer revealed the sizes of the fly ash and PEG-zeolite particles as 60± 10 μm and 50± 10 nm, respectively. The IDE surface was evaluated for its ability to display antifouling properties and sense glucose levels on the abovementioned nanoparticle-modified surface. Glucose oxidase was probed on the PEG-zeolite-modified IDE surface, and glucose was detected. PEG zeolite performed well with excellent antifouling properties on the IDE sensor surface and improved the glucose detection limit to 0.03 mg/mL from 0.08 mg/mL, as determined by linear regressions [y = 5.365x - 6.803; R2 = 0.9035 (zeolite surface) and y = 5.498x + 5.914R2 = 0.9061 (PEG-zeolite surface)]. This enhancement was &sim; 3-fold, and sensitivities were found to be 0.03 and 0.06 mg/mL glucose for the PEG-zeolite- and zeolite-modified surfaces, respectively, showing a 2-fold difference.Conclusion: The excellent biocompatible surface modified by PEG zeolite exhibited high performance and is useful for medical diagnosis.Keywords: blood glucose, dielectric sensor, biosensor, nanomaterial, nanoparticle
format	article
author	Chen Y Zhao Y Wang Y
author_facet	Chen Y Zhao Y Wang Y
author_sort	Chen Y
title	Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
title_short	Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
title_full	Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
title_fullStr	Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
title_full_unstemmed	Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus
title_sort	fly ash-based zeolite-complexed polyethylene-glycol on an interdigitated electrode surface for high-performance determination of diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/040a269650fc482198b767ac73ad19ed
work_keys_str_mv	AT cheny flyashbasedzeolitecomplexedpolyethyleneglycolonaninterdigitatedelectrodesurfaceforhighperformancedeterminationofdiabetesmellitus AT zhaoy flyashbasedzeolitecomplexedpolyethyleneglycolonaninterdigitatedelectrodesurfaceforhighperformancedeterminationofdiabetesmellitus AT wangy flyashbasedzeolitecomplexedpolyethyleneglycolonaninterdigitatedelectrodesurfaceforhighperformancedeterminationofdiabetesmellitus
_version_	1718393545718497280

Fly Ash-Based Zeolite-Complexed Polyethylene-Glycol on an Interdigitated Electrode Surface for High-Performance Determination of Diabetes Mellitus

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