Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study

Gashaw Dessie,1 Yewondwossen Tadesse,2 Birhanu Demelash,2 Solomon Genet3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiop...

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Autores principales:	Dessie G, Tadesse Y, Genet S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rheumatoid arthritis lipid profiles high sensitivity c-reactive protein Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/040b20604a9746889d8ee5bbd75229ef
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spelling	oai:doaj.org-article:040b20604a9746889d8ee5bbd75229ef2021-12-02T10:05:06ZAssessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study1179-156Xhttps://doaj.org/article/040b20604a9746889d8ee5bbd75229ef2020-09-01T00:00:00Zhttps://www.dovepress.com/assessment-of-serum-lipid-profiles-and-high-sensitivity-c-reactive-pro-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XGashaw Dessie,1 Yewondwossen Tadesse,2 Birhanu Demelash,2 Solomon Genet3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gashaw DessieDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaTel +251 975152796Email dessiegashaw@yahoo.comBackground: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by severe joint pain, swelling, damage, and disability which leads to joint destruction and loss of function. The complication of RA is associated with cardiovascular diseases, particularly due to systemic inflammation and dyslipidemia. The purpose of this study was to assess the development of atherosclerosis, which acts as a major risk factor for cardiovascular complications in RA patients.Methods: A hospital-based cross-sectional study was conducted at the Rheumatology Clinic of Tikur Anbessa Specialized Hospital. The study made a comparison of risk factors (dyslipidemia and inflammatory status) between individuals having RA as a case group and apparently healthy individuals as a control group. Simple descriptive statistics, one-way ANOVA, independent sample t-test and multivariate analysis were utilized for statistical analysis. p-value of < 0.05 at the 95% confidence level was considered as statistically significant.Results: The result of this study demonstrated that there was a significant elevation of mean ±SD of TC, TC/HDL, LDL/HDL, and lowered value of HDL-C was seen among RA patients than controls (P-value < 0.05). The mean ±SD of inflammatory marker, high-sensitivity C-reactive protein (hsCRP), was significantly higher among RA patients compared to controls (P< 0.05). HDL-C had a significant negative correlation with a hsCRP whereas TC/HDL-C and LDL/HDL-C had a significant positive correlation with hsCRP (P< 0.05).Conclusion: In this study, RA patients had lipid abnormalities and elevated systemic inflammation than controls. An increase in hsCRP and dyslipidemia status among RA patients indicates the possible development of an atherosclerotic event. Therefore, assessment of lipid profiles and hsCRP in early RA patients may be helpful to assess the possible development of cardiovascular complications.Keywords: rheumatoid arthritis, lipid profiles, high-sensitivity C-reactive proteinDessie GTadesse YGenet SDove Medical Pressarticlerheumatoid arthritislipid profileshigh sensitivity c-reactive proteinDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 223-232 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis lipid profiles high sensitivity c-reactive protein Diseases of the musculoskeletal system RC925-935
spellingShingle	rheumatoid arthritis lipid profiles high sensitivity c-reactive protein Diseases of the musculoskeletal system RC925-935 Dessie G Tadesse Y Genet S Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
description	Gashaw Dessie,1 Yewondwossen Tadesse,2 Birhanu Demelash,2 Solomon Genet3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Internal Medicine, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Biochemistry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gashaw DessieDepartment of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaTel +251 975152796Email dessiegashaw@yahoo.comBackground: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by severe joint pain, swelling, damage, and disability which leads to joint destruction and loss of function. The complication of RA is associated with cardiovascular diseases, particularly due to systemic inflammation and dyslipidemia. The purpose of this study was to assess the development of atherosclerosis, which acts as a major risk factor for cardiovascular complications in RA patients.Methods: A hospital-based cross-sectional study was conducted at the Rheumatology Clinic of Tikur Anbessa Specialized Hospital. The study made a comparison of risk factors (dyslipidemia and inflammatory status) between individuals having RA as a case group and apparently healthy individuals as a control group. Simple descriptive statistics, one-way ANOVA, independent sample t-test and multivariate analysis were utilized for statistical analysis. p-value of < 0.05 at the 95% confidence level was considered as statistically significant.Results: The result of this study demonstrated that there was a significant elevation of mean ±SD of TC, TC/HDL, LDL/HDL, and lowered value of HDL-C was seen among RA patients than controls (P-value < 0.05). The mean ±SD of inflammatory marker, high-sensitivity C-reactive protein (hsCRP), was significantly higher among RA patients compared to controls (P< 0.05). HDL-C had a significant negative correlation with a hsCRP whereas TC/HDL-C and LDL/HDL-C had a significant positive correlation with hsCRP (P< 0.05).Conclusion: In this study, RA patients had lipid abnormalities and elevated systemic inflammation than controls. An increase in hsCRP and dyslipidemia status among RA patients indicates the possible development of an atherosclerotic event. Therefore, assessment of lipid profiles and hsCRP in early RA patients may be helpful to assess the possible development of cardiovascular complications.Keywords: rheumatoid arthritis, lipid profiles, high-sensitivity C-reactive protein
format	article
author	Dessie G Tadesse Y Genet S
author_facet	Dessie G Tadesse Y Genet S
author_sort	Dessie G
title	Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
title_short	Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
title_full	Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
title_fullStr	Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
title_full_unstemmed	Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study
title_sort	assessment of serum lipid profiles and high-sensitivity c-reactive protein among patients suffering from rheumatoid arthritis at tikur anbessa specialized hospital, addis ababa, ethiopia: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/040b20604a9746889d8ee5bbd75229ef
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Assessment of Serum Lipid Profiles and High-sensitivity C-reactive Protein Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Cross-Sectional Study

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