Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization
Synthesis of aryl phosphorus compounds with electron-withdrawing substituents on the arene is difficult to do simply. Here the authors show a method to form aryl carbon-phosphorus bonds through electrochemistry, without requiring any catalyst or external oxidant.
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Nature Portfolio
2021
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oai:doaj.org-article:040c115128194231a97296b5b1a1ae002021-11-21T12:36:29ZElectrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization10.1038/s41467-021-26960-y2041-1723https://doaj.org/article/040c115128194231a97296b5b1a1ae002021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26960-yhttps://doaj.org/toc/2041-1723Synthesis of aryl phosphorus compounds with electron-withdrawing substituents on the arene is difficult to do simply. Here the authors show a method to form aryl carbon-phosphorus bonds through electrochemistry, without requiring any catalyst or external oxidant.Hao LongChong HuangYun-Tao ZhengZhao-Yu LiLiang-Hua JieJinshuai SongShaobin ZhuHai-Chao XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021) |
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Science Q Hao Long Chong Huang Yun-Tao Zheng Zhao-Yu Li Liang-Hua Jie Jinshuai Song Shaobin Zhu Hai-Chao Xu Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
description |
Synthesis of aryl phosphorus compounds with electron-withdrawing substituents on the arene is difficult to do simply. Here the authors show a method to form aryl carbon-phosphorus bonds through electrochemistry, without requiring any catalyst or external oxidant. |
format |
article |
author |
Hao Long Chong Huang Yun-Tao Zheng Zhao-Yu Li Liang-Hua Jie Jinshuai Song Shaobin Zhu Hai-Chao Xu |
author_facet |
Hao Long Chong Huang Yun-Tao Zheng Zhao-Yu Li Liang-Hua Jie Jinshuai Song Shaobin Zhu Hai-Chao Xu |
author_sort |
Hao Long |
title |
Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
title_short |
Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
title_full |
Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
title_fullStr |
Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
title_full_unstemmed |
Electrochemical C–H phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
title_sort |
electrochemical c–h phosphorylation of arenes in continuous flow suitable for late-stage functionalization |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/040c115128194231a97296b5b1a1ae00 |
work_keys_str_mv |
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1718418865638080512 |