Whole-genome sequencing of recurrent neuroblastoma reveals somatic mutations that affect key players in cancer progression and telomere maintenance

Abstract Neuroblastoma is the most common and deadly childhood tumor. Relapsed or refractory neuroblastoma has a very poor prognosis despite recent treatment advances. To investigate genomic alterations associated with relapse and therapy resistance, whole-genome sequencing was performed on diagnost...

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Autores principales: Susanne Fransson, Angela Martinez-Monleon, Mathias Johansson, Rose-Marie Sjöberg, Caroline Björklund, Gustaf Ljungman, Torben Ek, Per Kogner, Tommy Martinsson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/040e279adcf3445389b188aed659660d
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