Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content
ABSTRACT The four-cysteine zinc finger motif of the bacterial RNA polymerase regulator DksA is essential for protein structure, canonical control of the stringent response to nutritional limitation, and thiol-based sensing of oxidative and nitrosative stress. This interdependent relationship has lim...
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Main Authors: | Matthew A. Crawford, Timothy Tapscott, Liam F. Fitzsimmons, Lin Liu, Aníbal M. Reyes, Stephen J. Libby, Madia Trujillo, Ferric C. Fang, Rafael Radi, Andrés Vázquez-Torres |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2016
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Online Access: | https://doaj.org/article/0410db42924e46a1af7e678f52990e9d |
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