Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content

ABSTRACT The four-cysteine zinc finger motif of the bacterial RNA polymerase regulator DksA is essential for protein structure, canonical control of the stringent response to nutritional limitation, and thiol-based sensing of oxidative and nitrosative stress. This interdependent relationship has lim...

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Bibliographic Details
Main Authors: Matthew A. Crawford, Timothy Tapscott, Liam F. Fitzsimmons, Lin Liu, Aníbal M. Reyes, Stephen J. Libby, Madia Trujillo, Ferric C. Fang, Rafael Radi, Andrés Vázquez-Torres
Format: article
Language:EN
Published: American Society for Microbiology 2016
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Online Access:https://doaj.org/article/0410db42924e46a1af7e678f52990e9d
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