Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus

Abstract Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and...

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Autores principales:	Yunzhi Peter Yang, Kevin M. Labus, Benjamin C. Gadomski, Arnaud Bruyas, Jeremiah Easley, Brad Nelson, Ross H. Palmer, Kirk McGilvray, Daniel Regan, Christian M. Puttlitz, Alexander Stahl, Elaine Lui, Jiannan Li, Seyedsina Moeinzadeh, Sungwoo Kim, William Maloney, Michael J. Gardner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/041118049a384bd1920ca166cdd8d42f
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spelling	oai:doaj.org-article:041118049a384bd1920ca166cdd8d42f2021-12-02T16:36:03ZOsteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus10.1038/s41598-021-86210-52045-2322https://doaj.org/article/041118049a384bd1920ca166cdd8d42f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86210-5https://doaj.org/toc/2045-2322Abstract Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in a pilot feasibility study using a new sheep metatarsus fracture model stabilized with an intramedullary nail. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.Yunzhi Peter YangKevin M. LabusBenjamin C. GadomskiArnaud BruyasJeremiah EasleyBrad NelsonRoss H. PalmerKirk McGilvrayDaniel ReganChristian M. PuttlitzAlexander StahlElaine LuiJiannan LiSeyedsina MoeinzadehSungwoo KimWilliam MaloneyMichael J. GardnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunzhi Peter Yang Kevin M. Labus Benjamin C. Gadomski Arnaud Bruyas Jeremiah Easley Brad Nelson Ross H. Palmer Kirk McGilvray Daniel Regan Christian M. Puttlitz Alexander Stahl Elaine Lui Jiannan Li Seyedsina Moeinzadeh Sungwoo Kim William Maloney Michael J. Gardner Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
description	Abstract Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in a pilot feasibility study using a new sheep metatarsus fracture model stabilized with an intramedullary nail. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.
format	article
author	Yunzhi Peter Yang Kevin M. Labus Benjamin C. Gadomski Arnaud Bruyas Jeremiah Easley Brad Nelson Ross H. Palmer Kirk McGilvray Daniel Regan Christian M. Puttlitz Alexander Stahl Elaine Lui Jiannan Li Seyedsina Moeinzadeh Sungwoo Kim William Maloney Michael J. Gardner
author_facet	Yunzhi Peter Yang Kevin M. Labus Benjamin C. Gadomski Arnaud Bruyas Jeremiah Easley Brad Nelson Ross H. Palmer Kirk McGilvray Daniel Regan Christian M. Puttlitz Alexander Stahl Elaine Lui Jiannan Li Seyedsina Moeinzadeh Sungwoo Kim William Maloney Michael J. Gardner
author_sort	Yunzhi Peter Yang
title	Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
title_short	Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
title_full	Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
title_fullStr	Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
title_full_unstemmed	Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
title_sort	osteoinductive 3d printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/041118049a384bd1920ca166cdd8d42f
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Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus

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