Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis, which determines FN-RMS tumour identity.

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Autores principales:	Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Myron K. Evans, Kristin B. Reed, Madeline Bush, Jason A. Hanna, Catherine J. Drummond, Matthew C. Maguire, Patrick J. Leavey, David Finkelstein, Hongjian Jin, Patrick A. Schreiner, Jerold E. Rehg, Mark E. Hatley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0413e8410b0248ed86492edc2f4f4634
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spelling	oai:doaj.org-article:0413e8410b0248ed86492edc2f4f46342021-12-02T18:33:47ZSynthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity10.1038/s41467-021-25829-42041-1723https://doaj.org/article/0413e8410b0248ed86492edc2f4f46342021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25829-4https://doaj.org/toc/2041-1723PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis, which determines FN-RMS tumour identity.Casey G. LangdonKatherine E. GadekMatthew R. GarciaMyron K. EvansKristin B. ReedMadeline BushJason A. HannaCatherine J. DrummondMatthew C. MaguirePatrick J. LeaveyDavid FinkelsteinHongjian JinPatrick A. SchreinerJerold E. RehgMark E. HatleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Casey G. Langdon Katherine E. Gadek Matthew R. Garcia Myron K. Evans Kristin B. Reed Madeline Bush Jason A. Hanna Catherine J. Drummond Matthew C. Maguire Patrick J. Leavey David Finkelstein Hongjian Jin Patrick A. Schreiner Jerold E. Rehg Mark E. Hatley Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
description	PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis, which determines FN-RMS tumour identity.
format	article
author	Casey G. Langdon Katherine E. Gadek Matthew R. Garcia Myron K. Evans Kristin B. Reed Madeline Bush Jason A. Hanna Catherine J. Drummond Matthew C. Maguire Patrick J. Leavey David Finkelstein Hongjian Jin Patrick A. Schreiner Jerold E. Rehg Mark E. Hatley
author_facet	Casey G. Langdon Katherine E. Gadek Matthew R. Garcia Myron K. Evans Kristin B. Reed Madeline Bush Jason A. Hanna Catherine J. Drummond Matthew C. Maguire Patrick J. Leavey David Finkelstein Hongjian Jin Patrick A. Schreiner Jerold E. Rehg Mark E. Hatley
author_sort	Casey G. Langdon
title	Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
title_short	Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
title_full	Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
title_fullStr	Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
title_full_unstemmed	Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity
title_sort	synthetic essentiality between pten and core dependency factor pax7 dictates rhabdomyosarcoma identity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0413e8410b0248ed86492edc2f4f4634
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Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity

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