Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma

Abstract Total metabolic tumor volume (TMTV) is a promising quantitative biomarker for therapy assessment and prognosis in Hodgkin Lymphoma affected patients that allows prediction of patient outcome. The aim of this study was to evaluate the TMTV reproducibility between different sources of variabi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Queralt Martín-Saladich, Gabriel Reynés-Llompart, Aida Sabaté-Llobera, Azahara Palomar-Muñoz, Eva Domingo-Domènech, Montse Cortés-Romera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/041585768bed4740bcb6b7a7d5e1a5f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:041585768bed4740bcb6b7a7d5e1a5f8
record_format	dspace
spelling	oai:doaj.org-article:041585768bed4740bcb6b7a7d5e1a5f82021-12-02T16:06:40ZComparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma10.1038/s41598-020-69577-92045-2322https://doaj.org/article/041585768bed4740bcb6b7a7d5e1a5f82020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69577-9https://doaj.org/toc/2045-2322Abstract Total metabolic tumor volume (TMTV) is a promising quantitative biomarker for therapy assessment and prognosis in Hodgkin Lymphoma affected patients that allows prediction of patient outcome. The aim of this study was to evaluate the TMTV reproducibility between different sources of variability in tumor delimitation such as SUV-based thresholds (2.5, 41% and 50%) and software tools (Beth Israel plugin (BI) and LIFEx). Effect of contouring procedure both including single and multiple regions of interest was also studied in patients with multiple lesions, and optimal cut-offs for each studied method were displayed to compare the effect on prognosis. Strong alikeness in TMTV was found for 2.5 under software choice. Best accuracy in contouring compared to visual assessment of the disease was found for BI multiple ROI and LIFEx single ROI drawing. Similar cut-offs were found between both software for all considered thresholds, but best resemblance and highest cut-off due to an overestimation of the TMTV was found for 2.5 SUV. Our findings suggest that optimal reproducibility in TMTV is found for SUV > 2.5 threshold under choice of contouring methodology or software tool, meaning that overestimation of the TMTV threshold using 2.5 looks to be preferable than underestimation with 41% and 50%.Queralt Martín-SaladichGabriel Reynés-LlompartAida Sabaté-LloberaAzahara Palomar-MuñozEva Domingo-DomènechMontse Cortés-RomeraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Queralt Martín-Saladich Gabriel Reynés-Llompart Aida Sabaté-Llobera Azahara Palomar-Muñoz Eva Domingo-Domènech Montse Cortés-Romera Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
description	Abstract Total metabolic tumor volume (TMTV) is a promising quantitative biomarker for therapy assessment and prognosis in Hodgkin Lymphoma affected patients that allows prediction of patient outcome. The aim of this study was to evaluate the TMTV reproducibility between different sources of variability in tumor delimitation such as SUV-based thresholds (2.5, 41% and 50%) and software tools (Beth Israel plugin (BI) and LIFEx). Effect of contouring procedure both including single and multiple regions of interest was also studied in patients with multiple lesions, and optimal cut-offs for each studied method were displayed to compare the effect on prognosis. Strong alikeness in TMTV was found for 2.5 under software choice. Best accuracy in contouring compared to visual assessment of the disease was found for BI multiple ROI and LIFEx single ROI drawing. Similar cut-offs were found between both software for all considered thresholds, but best resemblance and highest cut-off due to an overestimation of the TMTV was found for 2.5 SUV. Our findings suggest that optimal reproducibility in TMTV is found for SUV > 2.5 threshold under choice of contouring methodology or software tool, meaning that overestimation of the TMTV threshold using 2.5 looks to be preferable than underestimation with 41% and 50%.
format	article
author	Queralt Martín-Saladich Gabriel Reynés-Llompart Aida Sabaté-Llobera Azahara Palomar-Muñoz Eva Domingo-Domènech Montse Cortés-Romera
author_facet	Queralt Martín-Saladich Gabriel Reynés-Llompart Aida Sabaté-Llobera Azahara Palomar-Muñoz Eva Domingo-Domènech Montse Cortés-Romera
author_sort	Queralt Martín-Saladich
title	Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
title_short	Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
title_full	Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
title_fullStr	Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
title_full_unstemmed	Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma
title_sort	comparison of different automatic methods for the delineation of the total metabolic tumor volume in i–ii stage hodgkin lymphoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/041585768bed4740bcb6b7a7d5e1a5f8
work_keys_str_mv	AT queraltmartinsaladich comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma AT gabrielreynesllompart comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma AT aidasabatellobera comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma AT azaharapalomarmunoz comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma AT evadomingodomenech comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma AT montsecortesromera comparisonofdifferentautomaticmethodsforthedelineationofthetotalmetabolictumorvolumeiniiistagehodgkinlymphoma
_version_	1718384882753732608

Comparison of different automatic methods for the delineation of the total metabolic tumor volume in I–II stage Hodgkin Lymphoma

Ejemplares similares