KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic calcium signals.

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Autores principales:	Nagendra Babu Thillaiappan, Holly A. Smith, Peace Atakpa-Adaji, Colin W. Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/04166b2ae3fa4b2f9f034934aef56261
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spelling	oai:doaj.org-article:04166b2ae3fa4b2f9f034934aef562612021-12-02T16:17:57ZKRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals10.1038/s41467-021-24739-92041-1723https://doaj.org/article/04166b2ae3fa4b2f9f034934aef562612021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24739-9https://doaj.org/toc/2041-1723Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic calcium signals.Nagendra Babu ThillaiappanHolly A. SmithPeace Atakpa-AdajiColin W. TaylorNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nagendra Babu Thillaiappan Holly A. Smith Peace Atakpa-Adaji Colin W. Taylor KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
description	Calcium signals initiated by IP3 receptors in ER membranes regulate most cellular activities. Here, the authors show that KRas-induced actininteracting protein (KRAP) tethers a small subset of IP3 receptors to actin and licenses them to evoke cytosolic calcium signals.
format	article
author	Nagendra Babu Thillaiappan Holly A. Smith Peace Atakpa-Adaji Colin W. Taylor
author_facet	Nagendra Babu Thillaiappan Holly A. Smith Peace Atakpa-Adaji Colin W. Taylor
author_sort	Nagendra Babu Thillaiappan
title	KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
title_short	KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
title_full	KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
title_fullStr	KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
title_full_unstemmed	KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
title_sort	krap tethers ip3 receptors to actin and licenses them to evoke cytosolic ca2+ signals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/04166b2ae3fa4b2f9f034934aef56261
work_keys_str_mv	AT nagendrababuthillaiappan kraptethersip3receptorstoactinandlicensesthemtoevokecytosolicca2signals AT hollyasmith kraptethersip3receptorstoactinandlicensesthemtoevokecytosolicca2signals AT peaceatakpaadaji kraptethersip3receptorstoactinandlicensesthemtoevokecytosolicca2signals AT colinwtaylor kraptethersip3receptorstoactinandlicensesthemtoevokecytosolicca2signals
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KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals

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