Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration

Gut microbiota and their metabolites regulate homeostasis of the intestine, but their effects on intestine development are unclear. Here the authors use RNAseq and germ free mice to show that intestinal microbiota promote the expression of Erdr1, which increases Lgr5+ intestinal stem cell number and...

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Autores principales:	Hirohito Abo, Benoit Chassaing, Akihito Harusato, Miguel Quiros, Jennifer C. Brazil, Vu L. Ngo, Emilie Viennois, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/041717f946814996be968b7a702f6fb1
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spelling	oai:doaj.org-article:041717f946814996be968b7a702f6fb12021-12-02T15:39:25ZErythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration10.1038/s41467-019-14258-z2041-1723https://doaj.org/article/041717f946814996be968b7a702f6fb12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14258-zhttps://doaj.org/toc/2041-1723Gut microbiota and their metabolites regulate homeostasis of the intestine, but their effects on intestine development are unclear. Here the authors use RNAseq and germ free mice to show that intestinal microbiota promote the expression of Erdr1, which increases Lgr5+ intestinal stem cell number and activity.Hirohito AboBenoit ChassaingAkihito HarusatoMiguel QuirosJennifer C. BrazilVu L. NgoEmilie ViennoisDidier MerlinAndrew T. GewirtzAsma NusratTimothy L. DenningNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hirohito Abo Benoit Chassaing Akihito Harusato Miguel Quiros Jennifer C. Brazil Vu L. Ngo Emilie Viennois Didier Merlin Andrew T. Gewirtz Asma Nusrat Timothy L. Denning Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
description	Gut microbiota and their metabolites regulate homeostasis of the intestine, but their effects on intestine development are unclear. Here the authors use RNAseq and germ free mice to show that intestinal microbiota promote the expression of Erdr1, which increases Lgr5+ intestinal stem cell number and activity.
format	article
author	Hirohito Abo Benoit Chassaing Akihito Harusato Miguel Quiros Jennifer C. Brazil Vu L. Ngo Emilie Viennois Didier Merlin Andrew T. Gewirtz Asma Nusrat Timothy L. Denning
author_facet	Hirohito Abo Benoit Chassaing Akihito Harusato Miguel Quiros Jennifer C. Brazil Vu L. Ngo Emilie Viennois Didier Merlin Andrew T. Gewirtz Asma Nusrat Timothy L. Denning
author_sort	Hirohito Abo
title	Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
title_short	Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
title_full	Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
title_fullStr	Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
title_full_unstemmed	Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
title_sort	erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/041717f946814996be968b7a702f6fb1
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Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration

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