A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis
Binny Thomas,1-3 Mahmoud Mohamed,1,3,4 Moza Al Hail,1-3 Fatma Alzahra Y Awwad,1 Ramy M Wahba,1 Sabir B Hassan,1 Khalid Omar,1 Wessam El Kassem,1 Palivalappila Abdul Rouf1 1Hamad Medical Corporation, Doha, Qatar; 2Robert Gordon University, Aberdeen, Scotland, UK; 3Qatar University, Doha, 4We...
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Dove Medical Press
2016
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oai:doaj.org-article:0418dc569a904999967768d7b49323582021-12-02T00:53:38ZA case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis1179-1438https://doaj.org/article/0418dc569a904999967768d7b49323582016-12-01T00:00:00Zhttps://www.dovepress.com/a-case-of-probable-esomeprazole-induced-transient-liver-injury-in-a-pr-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Binny Thomas,1-3 Mahmoud Mohamed,1,3,4 Moza Al Hail,1-3 Fatma Alzahra Y Awwad,1 Ramy M Wahba,1 Sabir B Hassan,1 Khalid Omar,1 Wessam El Kassem,1 Palivalappila Abdul Rouf1 1Hamad Medical Corporation, Doha, Qatar; 2Robert Gordon University, Aberdeen, Scotland, UK; 3Qatar University, Doha, 4Weill Cornell Medical College, Ar-Rayyan, Qatar Abstract: We report a case of 22-year-old primigravida presented to Women’s Hospital – Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3 weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as “probably”. Keywords: hyperemesis, drug-induced liver injury, esomeprazole, adverse drug reaction, ADR, proton pump inhibitorThomas BMohamed MAl Hail MAwwad FAWahba RMHassan SBOmar KEl Kassem WAbdul Rouf PDove Medical PressarticleHyperemesisDrug Induced liver InjuryDILIEsomeprazoleAdverse Drug ReactionADR. Proton Pump inhibitorTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 8, Pp 199-202 (2016) |
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DOAJ |
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DOAJ |
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EN |
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Hyperemesis Drug Induced liver Injury DILI Esomeprazole Adverse Drug Reaction ADR. Proton Pump inhibitor Therapeutics. Pharmacology RM1-950 |
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Hyperemesis Drug Induced liver Injury DILI Esomeprazole Adverse Drug Reaction ADR. Proton Pump inhibitor Therapeutics. Pharmacology RM1-950 Thomas B Mohamed M Al Hail M Awwad FA Wahba RM Hassan SB Omar K El Kassem W Abdul Rouf P A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| description |
Binny Thomas,1-3 Mahmoud Mohamed,1,3,4 Moza Al Hail,1-3 Fatma Alzahra Y Awwad,1 Ramy M Wahba,1 Sabir B Hassan,1 Khalid Omar,1 Wessam El Kassem,1 Palivalappila Abdul Rouf1 1Hamad Medical Corporation, Doha, Qatar; 2Robert Gordon University, Aberdeen, Scotland, UK; 3Qatar University, Doha, 4Weill Cornell Medical College, Ar-Rayyan, Qatar Abstract: We report a case of 22-year-old primigravida presented to Women’s Hospital – Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3 weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as “probably”. Keywords: hyperemesis, drug-induced liver injury, esomeprazole, adverse drug reaction, ADR, proton pump inhibitor |
| format |
article |
| author |
Thomas B Mohamed M Al Hail M Awwad FA Wahba RM Hassan SB Omar K El Kassem W Abdul Rouf P |
| author_facet |
Thomas B Mohamed M Al Hail M Awwad FA Wahba RM Hassan SB Omar K El Kassem W Abdul Rouf P |
| author_sort |
Thomas B |
| title |
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| title_short |
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| title_full |
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| title_fullStr |
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| title_full_unstemmed |
A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| title_sort |
case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/0418dc569a904999967768d7b4932358 |
| work_keys_str_mv |
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1718403416102797312 |