Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients
Аbstrасt Introduction This study aims to investigate in‐hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. Methods Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). Results Approximately 89% (118)...
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Wiley
2021
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oai:doaj.org-article:041a0f6d35ed4491887a4a3b325f0bc52021-11-12T19:57:15ZFerritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients2050-452710.1002/iid3.517https://doaj.org/article/041a0f6d35ed4491887a4a3b325f0bc52021-12-01T00:00:00Zhttps://doi.org/10.1002/iid3.517https://doaj.org/toc/2050-4527Аbstrасt Introduction This study aims to investigate in‐hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. Methods Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). Results Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p < .001) had significance in predicting in‐hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. Conclusion In this study, higher levels of serum ferritin were found to be an independent predictor of in‐hоsрitаl mоrtаlity.Moudhi AlroomiRajesh RajanAbdulaziz A. OmarAhmad AlsaberJiazhu PanMina FatemiProf Kobalava D. ZhannaWael AboelhassanFarah AlmutairiNaser AlotaibiMohammad A. SalehNoor AlNasrallahBader Al‐BaderHaya MalhasMaryam RamadhanMohammed AbdullahHassan AbdelnabyWileyarticleCOVID‐19ferritinhypertensionin‐hospital mortalitymale sexpneumoniaImmunologic diseases. AllergyRC581-607ENImmunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1648-1655 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
COVID‐19 ferritin hypertension in‐hospital mortality male sex pneumonia Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
COVID‐19 ferritin hypertension in‐hospital mortality male sex pneumonia Immunologic diseases. Allergy RC581-607 Moudhi Alroomi Rajesh Rajan Abdulaziz A. Omar Ahmad Alsaber Jiazhu Pan Mina Fatemi Prof Kobalava D. Zhanna Wael Aboelhassan Farah Almutairi Naser Alotaibi Mohammad A. Saleh Noor AlNasrallah Bader Al‐Bader Haya Malhas Maryam Ramadhan Mohammed Abdullah Hassan Abdelnaby Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| description |
Аbstrасt Introduction This study aims to investigate in‐hоsрitаl mоrtаlity in severe асute resрirаtоry syndrоme соrоnаvirus 2 раtients strаtified by serum ferritin levels. Methods Patients were stratified based on ferritin levels (ferritin levels ≤ 1000 or >1000). Results Approximately 89% (118) of the patients with ferritin levels > 1000 had pneumonia, and 51% (67) had hypertension. Fever (97, 73.5%) and shortness of breath (80, 61%) were two major symptoms among the patients in this group. Logistic regression analysis indicated that ferritin level (odds ratio [OR] = 0.36, 95% confidence interval [CI] = 0.21–0.62; p < .001), male sex (OR = 2.63, 95% CI = 1.43–5.06; p = .003), hypertension (OR = 4.16, 95% CI = 2.42–7.36; p < .001) and pneumonia (OR = 8.48, 95% CI = 3.02–35.45; p < .001) had significance in predicting in‐hospital mortality. Additionally, the Cox proportional hazards analysis and Kaplan–Meier survival probability plot showed a higher mortality rate among patients with ferritin levels > 1000. Conclusion In this study, higher levels of serum ferritin were found to be an independent predictor of in‐hоsрitаl mоrtаlity. |
| format |
article |
| author |
Moudhi Alroomi Rajesh Rajan Abdulaziz A. Omar Ahmad Alsaber Jiazhu Pan Mina Fatemi Prof Kobalava D. Zhanna Wael Aboelhassan Farah Almutairi Naser Alotaibi Mohammad A. Saleh Noor AlNasrallah Bader Al‐Bader Haya Malhas Maryam Ramadhan Mohammed Abdullah Hassan Abdelnaby |
| author_facet |
Moudhi Alroomi Rajesh Rajan Abdulaziz A. Omar Ahmad Alsaber Jiazhu Pan Mina Fatemi Prof Kobalava D. Zhanna Wael Aboelhassan Farah Almutairi Naser Alotaibi Mohammad A. Saleh Noor AlNasrallah Bader Al‐Bader Haya Malhas Maryam Ramadhan Mohammed Abdullah Hassan Abdelnaby |
| author_sort |
Moudhi Alroomi |
| title |
Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| title_short |
Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| title_full |
Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| title_fullStr |
Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| title_full_unstemmed |
Ferritin level: A predictor of severity and mortality in hospitalized COVID‐19 patients |
| title_sort |
ferritin level: a predictor of severity and mortality in hospitalized covid‐19 patients |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/041a0f6d35ed4491887a4a3b325f0bc5 |
| work_keys_str_mv |
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