Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.

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Autores principales:	Huiyun Peng, Keishi Ishida, Yuki Sugimoto, Holger Jenke-Kodama, Christian Hertweck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/041fa1b775d04addb61bca3fe0deb5c9
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spelling	oai:doaj.org-article:041fa1b775d04addb61bca3fe0deb5c92021-12-02T15:35:17ZEmulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases10.1038/s41467-019-11896-12041-1723https://doaj.org/article/041fa1b775d04addb61bca3fe0deb5c92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11896-1https://doaj.org/toc/2041-1723The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.Huiyun PengKeishi IshidaYuki SugimotoHolger Jenke-KodamaChristian HertweckNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huiyun Peng Keishi Ishida Yuki Sugimoto Holger Jenke-Kodama Christian Hertweck Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
description	The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.
format	article
author	Huiyun Peng Keishi Ishida Yuki Sugimoto Holger Jenke-Kodama Christian Hertweck
author_facet	Huiyun Peng Keishi Ishida Yuki Sugimoto Holger Jenke-Kodama Christian Hertweck
author_sort	Huiyun Peng
title	Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
title_short	Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
title_full	Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
title_fullStr	Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
title_full_unstemmed	Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
title_sort	emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/041fa1b775d04addb61bca3fe0deb5c9
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Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

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