Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases

The wealth of complex polyketides is an essential source for drug discovery. Here, the authors report an evolution-guided rational morphing of modular polyketide synthases (PKSs) for aurothin and neoaurothin biosynthesis, and reveal engineering site suitable for diversifying PKS systems.

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Detalles Bibliográficos
Autores principales: Huiyun Peng, Keishi Ishida, Yuki Sugimoto, Holger Jenke-Kodama, Christian Hertweck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/041fa1b775d04addb61bca3fe0deb5c9
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