Mucuna pruriens (Velvet bean) rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

Mucuna pruriens (Velvet bean) rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

The fruit fly Drosophila melanogaster (Dm) mutant for PTEN-induced putative kinase 1 (PINK1B9) gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD). Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe), a L-Dopa-conta...

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Autores principales: Simone Poddighe, Francescaelena De Rose, Roberto Marotta, Roberta Ruffilli, Maura Fanti, Pietro Paolo Secci, Maria Cristina Mostallino, Maria Dolores Setzu, Maria Antonietta Zuncheddu, Ignazio Collu, Paolo Solla, Francesco Marrosu, Sanjay Kasture, Elio Acquas, Anna Liscia
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0421bc6e351f4e948131a0aebfbe0375
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