Neurosurgical strategies for Gilles de la Tourette’s syndrome
Karim Mukhida1,2, Matthew Bishop2, Murray Hong2, Ivar Mendez21Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; 2Departments, of Anatomy and Neurobiology and Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, CanadaAbstract: Tourette’s syndrome...
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Dove Medical Press
2008
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oai:doaj.org-article:04232e30ee094f12b3300c5b8b73c0002021-12-02T00:27:00ZNeurosurgical strategies for Gilles de la Tourette’s syndrome1176-63281178-2021https://doaj.org/article/04232e30ee094f12b3300c5b8b73c0002008-09-01T00:00:00Zhttp://www.dovepress.com/neurosurgical-strategies-for-gilles-de-la-tourettersquos-syndrome-a2318https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Karim Mukhida1,2, Matthew Bishop2, Murray Hong2, Ivar Mendez21Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; 2Departments, of Anatomy and Neurobiology and Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, CanadaAbstract: Tourette’s syndrome (TS) is a neurological disorder characterized by motor and vocal tics that typically begin in childhood and often are accompanied by psychiatric comorbidities. Symptoms of TS may be socially disabling and cause secondary medical complications. Pharmacological therapies remain the mainstay of symptom management. For the subset of patients in whom TS symptoms are medically recalcitrant and do not dissipate by adulthood, neurosurgery may offer an alternative treatment strategy. Greater understanding of the neuroanatomic and pathophysiologic basis of TS has facilitated the development of surgical procedures that aim to ameliorate TS symptoms by lesions or deep brain stimulation of cerebral structures. Herein, the rationale for the surgical management of TS is discussed and neurosurgical experiences since the 1960s are reviewed. The necessity for neurosurgical strategies to be performed with appropriate ethical considerations is highlighted.Keywords: tourette’s syndrome, neurosurgery, deep brain stimulation, thalamus Karim MukhidaMatthew BishopMurray HongIvar MendezDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1111-1128 (2008) |
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DOAJ |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Karim Mukhida Matthew Bishop Murray Hong Ivar Mendez Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| description |
Karim Mukhida1,2, Matthew Bishop2, Murray Hong2, Ivar Mendez21Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada; 2Departments, of Anatomy and Neurobiology and Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, CanadaAbstract: Tourette’s syndrome (TS) is a neurological disorder characterized by motor and vocal tics that typically begin in childhood and often are accompanied by psychiatric comorbidities. Symptoms of TS may be socially disabling and cause secondary medical complications. Pharmacological therapies remain the mainstay of symptom management. For the subset of patients in whom TS symptoms are medically recalcitrant and do not dissipate by adulthood, neurosurgery may offer an alternative treatment strategy. Greater understanding of the neuroanatomic and pathophysiologic basis of TS has facilitated the development of surgical procedures that aim to ameliorate TS symptoms by lesions or deep brain stimulation of cerebral structures. Herein, the rationale for the surgical management of TS is discussed and neurosurgical experiences since the 1960s are reviewed. The necessity for neurosurgical strategies to be performed with appropriate ethical considerations is highlighted.Keywords: tourette’s syndrome, neurosurgery, deep brain stimulation, thalamus |
| format |
article |
| author |
Karim Mukhida Matthew Bishop Murray Hong Ivar Mendez |
| author_facet |
Karim Mukhida Matthew Bishop Murray Hong Ivar Mendez |
| author_sort |
Karim Mukhida |
| title |
Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| title_short |
Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| title_full |
Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| title_fullStr |
Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| title_full_unstemmed |
Neurosurgical strategies for Gilles de la Tourette’s syndrome |
| title_sort |
neurosurgical strategies for gilles de la tourette’s syndrome |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/04232e30ee094f12b3300c5b8b73c000 |
| work_keys_str_mv |
AT karimmukhida neurosurgicalstrategiesforgillesdelatouretteamprsquossyndrome AT matthewbishop neurosurgicalstrategiesforgillesdelatouretteamprsquossyndrome AT murrayhong neurosurgicalstrategiesforgillesdelatouretteamprsquossyndrome AT ivarmendez neurosurgicalstrategiesforgillesdelatouretteamprsquossyndrome |
| _version_ |
1718403718710296576 |