Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment

Nilüfer Dönmezdil, Mehmet Uğur Çevik, Hasan Hüseyin Özdemir, Muhterem Taşin Department of Neurology, Dicle University, Diyarbakır, Turkey Purpose: There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxid...

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Autores principales:	Dönmezdil N, Çevik MU, Özdemir HH, Taşin M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epilepsy Paraoxonase 1 Malondialdehyde Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0426c847c2804c8995dd37ad4001290e
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spelling	oai:doaj.org-article:0426c847c2804c8995dd37ad4001290e2021-12-02T09:59:16ZInvestigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment1178-2021https://doaj.org/article/0426c847c2804c8995dd37ad4001290e2016-04-01T00:00:00Zhttps://www.dovepress.com/investigation-of-pon1-activity-and-mda-levels-in-patients-with-epileps-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Nilüfer Dönmezdil, Mehmet Uğur Çevik, Hasan Hüseyin Özdemir, Muhterem Taşin Department of Neurology, Dicle University, Diyarbakır, Turkey Purpose: There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxidative and antioxidant indicators of etiopathogenesis have also been examined under the scope. Drawing on a group of patients with epilepsy who were receiving no treatment, we have tried to evaluate whether or not an increase in oxidative indicators is linked directly with the disorder, independent of epileptic medicaments.Methods: Thirty people in good health and 30 newly diagnosed with epilepsy and who received ambulatory treatment in the polyclinic of the Neurology Department took part in the study. The tests relating to serum malondialdehyde (MDA) levels and paraoxonase 1 (PON1) activity were carried out in the biochemistry laboratory.Results: Even though the levels of MDA in the patient group (14.34±3.59 nmol/mL) were found to be high compared to those of the control group, which consisted of people in good health (13.53±3.56 nmol/mL), there was no statistically significant difference. PON1 activity in the serum taken from people in the patient group (0.65±0.17) was lower in comparison to that observed in the serum of the control group (0.71±0.17 U/L). Nonetheless, it was not so low as to have significance from a statistical point of view.Conclusion: We conclude that such a high level of oxidative parameters should have been related to the disease and that statistically significant findings that emerged in some other studies could have been related to an antiepileptic treatment. Keywords: epilepsy, paraoxonase 1, malondialdehyde, oxidative stress, epilepsy, biochemical markerDönmezdil NÇevik MUÖzdemir HHTaşin MDove Medical PressarticleEpilepsyParaoxonase 1MalondialdehydeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1013-1017 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epilepsy Paraoxonase 1 Malondialdehyde Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Epilepsy Paraoxonase 1 Malondialdehyde Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Dönmezdil N Çevik MU Özdemir HH Taşin M Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
description	Nilüfer Dönmezdil, Mehmet Uğur Çevik, Hasan Hüseyin Özdemir, Muhterem Taşin Department of Neurology, Dicle University, Diyarbakır, Turkey Purpose: There are many studies dedicated to researching the etiopathogenesis of epilepsy. In such research, oxidative and antioxidant indicators of etiopathogenesis have also been examined under the scope. Drawing on a group of patients with epilepsy who were receiving no treatment, we have tried to evaluate whether or not an increase in oxidative indicators is linked directly with the disorder, independent of epileptic medicaments.Methods: Thirty people in good health and 30 newly diagnosed with epilepsy and who received ambulatory treatment in the polyclinic of the Neurology Department took part in the study. The tests relating to serum malondialdehyde (MDA) levels and paraoxonase 1 (PON1) activity were carried out in the biochemistry laboratory.Results: Even though the levels of MDA in the patient group (14.34±3.59 nmol/mL) were found to be high compared to those of the control group, which consisted of people in good health (13.53±3.56 nmol/mL), there was no statistically significant difference. PON1 activity in the serum taken from people in the patient group (0.65±0.17) was lower in comparison to that observed in the serum of the control group (0.71±0.17 U/L). Nonetheless, it was not so low as to have significance from a statistical point of view.Conclusion: We conclude that such a high level of oxidative parameters should have been related to the disease and that statistically significant findings that emerged in some other studies could have been related to an antiepileptic treatment. Keywords: epilepsy, paraoxonase 1, malondialdehyde, oxidative stress, epilepsy, biochemical marker
format	article
author	Dönmezdil N Çevik MU Özdemir HH Taşin M
author_facet	Dönmezdil N Çevik MU Özdemir HH Taşin M
author_sort	Dönmezdil N
title	Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
title_short	Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
title_full	Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
title_fullStr	Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
title_full_unstemmed	Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment
title_sort	investigation of pon1 activity and mda levels in patients with epilepsy not receiving antiepileptic treatment
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0426c847c2804c8995dd37ad4001290e
work_keys_str_mv	AT donmezdiln investigationofpon1activityandmdalevelsinpatientswithepilepsynotreceivingantiepileptictreatment AT cevikmu investigationofpon1activityandmdalevelsinpatientswithepilepsynotreceivingantiepileptictreatment AT ozdemirhh investigationofpon1activityandmdalevelsinpatientswithepilepsynotreceivingantiepileptictreatment AT tasinm investigationofpon1activityandmdalevelsinpatientswithepilepsynotreceivingantiepileptictreatment
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Investigation of PON1 activity and MDA levels in patients with epilepsy not receiving antiepileptic treatment

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