The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

The aggressive nature of melanoma cells relies on their ability to switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state; however, the mechanisms governing this switch are unclear. Here, using in vivo models of human melanoma, the authors show that CD271 is a key r...

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Autores principales:	Gaetana Restivo, Johanna Diener, Phil F. Cheng, Gregor Kiowski, Mario Bonalli, Thomas Biedermann, Ernst Reichmann, Mitchell P. Levesque, Reinhard Dummer, Lukas Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0428808b8a974654b2d8209ef74be646
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spelling	oai:doaj.org-article:0428808b8a974654b2d8209ef74be6462021-12-02T15:38:43ZThe low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma10.1038/s41467-017-01573-62041-1723https://doaj.org/article/0428808b8a974654b2d8209ef74be6462017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01573-6https://doaj.org/toc/2041-1723The aggressive nature of melanoma cells relies on their ability to switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state; however, the mechanisms governing this switch are unclear. Here, using in vivo models of human melanoma, the authors show that CD271 is a key regulator of phenotype switching and metastasis formation.Gaetana RestivoJohanna DienerPhil F. ChengGregor KiowskiMario BonalliThomas BiedermannErnst ReichmannMitchell P. LevesqueReinhard DummerLukas SommerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gaetana Restivo Johanna Diener Phil F. Cheng Gregor Kiowski Mario Bonalli Thomas Biedermann Ernst Reichmann Mitchell P. Levesque Reinhard Dummer Lukas Sommer The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
description	The aggressive nature of melanoma cells relies on their ability to switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state; however, the mechanisms governing this switch are unclear. Here, using in vivo models of human melanoma, the authors show that CD271 is a key regulator of phenotype switching and metastasis formation.
format	article
author	Gaetana Restivo Johanna Diener Phil F. Cheng Gregor Kiowski Mario Bonalli Thomas Biedermann Ernst Reichmann Mitchell P. Levesque Reinhard Dummer Lukas Sommer
author_facet	Gaetana Restivo Johanna Diener Phil F. Cheng Gregor Kiowski Mario Bonalli Thomas Biedermann Ernst Reichmann Mitchell P. Levesque Reinhard Dummer Lukas Sommer
author_sort	Gaetana Restivo
title	The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
title_short	The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
title_full	The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
title_fullStr	The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
title_full_unstemmed	The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma
title_sort	low affinity neurotrophin receptor cd271 regulates phenotype switching in melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0428808b8a974654b2d8209ef74be646
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The low affinity neurotrophin receptor CD271 regulates phenotype switching in melanoma

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