Live-imaging rate-of-kill compound profiling for Chagas disease drug discovery with a new automated high-content assay.
Chagas disease, caused by the protozoan intracellular parasite Trypanosoma cruzi, is a highly neglected tropical disease, causing significant morbidity and mortality in central and south America. Current treatments are inadequate, and recent clinical trials of drugs inhibiting CYP51 have failed, exp...
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| Main Authors: | , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Public Library of Science (PLoS)
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/0428e734a42f4d65a9fe295ff74ee419 |
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