Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography

Abstract Ciliary motion plays a critical role in the overall respiratory health of the upper airway. These cilia beat at a native frequency and in a synchronized pattern to continuously transport foreign particulate trapped in a layer of mucous out of the upper airway. Disruption of ciliary motion c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joseph C. Jing, Jason J. Chen, Lidek Chou, Brian J. F. Wong, Zhongping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/043104215bed49ed91b75e8fb6ba0d80
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:043104215bed49ed91b75e8fb6ba0d80
record_format	dspace
spelling	oai:doaj.org-article:043104215bed49ed91b75e8fb6ba0d802021-12-02T15:06:00ZVisualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography10.1038/s41598-017-08968-x2045-2322https://doaj.org/article/043104215bed49ed91b75e8fb6ba0d802017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08968-xhttps://doaj.org/toc/2045-2322Abstract Ciliary motion plays a critical role in the overall respiratory health of the upper airway. These cilia beat at a native frequency and in a synchronized pattern to continuously transport foreign particulate trapped in a layer of mucous out of the upper airway. Disruption of ciliary motion can lead to severe respiratory diseases and compromised respiratory function. Currently, the study of cilia requires expensive high speed cameras and high powered microscopes which is unsuitable for in vivo imaging and diagnosis. Doppler based optical coherence tomography has the potential to visualize the microscopic motion of cilia during their beating cycle. We demonstrate the development of a high-speed Doppler optical coherence tomography system that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cilia function.Joseph C. JingJason J. ChenLidek ChouBrian J. F. WongZhongping ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph C. Jing Jason J. Chen Lidek Chou Brian J. F. Wong Zhongping Chen Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
description	Abstract Ciliary motion plays a critical role in the overall respiratory health of the upper airway. These cilia beat at a native frequency and in a synchronized pattern to continuously transport foreign particulate trapped in a layer of mucous out of the upper airway. Disruption of ciliary motion can lead to severe respiratory diseases and compromised respiratory function. Currently, the study of cilia requires expensive high speed cameras and high powered microscopes which is unsuitable for in vivo imaging and diagnosis. Doppler based optical coherence tomography has the potential to visualize the microscopic motion of cilia during their beating cycle. We demonstrate the development of a high-speed Doppler optical coherence tomography system that not only can rapidly determine the cilia beat frequency, but also simultaneously visualize the temporal cilia beating pattern which plays critical roles in cilia function.
format	article
author	Joseph C. Jing Jason J. Chen Lidek Chou Brian J. F. Wong Zhongping Chen
author_facet	Joseph C. Jing Jason J. Chen Lidek Chou Brian J. F. Wong Zhongping Chen
author_sort	Joseph C. Jing
title	Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
title_short	Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
title_full	Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
title_fullStr	Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
title_full_unstemmed	Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography
title_sort	visualization and detection of ciliary beating pattern and frequency in the upper airway using phase resolved doppler optical coherence tomography
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/043104215bed49ed91b75e8fb6ba0d80
work_keys_str_mv	AT josephcjing visualizationanddetectionofciliarybeatingpatternandfrequencyintheupperairwayusingphaseresolveddoppleropticalcoherencetomography AT jasonjchen visualizationanddetectionofciliarybeatingpatternandfrequencyintheupperairwayusingphaseresolveddoppleropticalcoherencetomography AT lidekchou visualizationanddetectionofciliarybeatingpatternandfrequencyintheupperairwayusingphaseresolveddoppleropticalcoherencetomography AT brianjfwong visualizationanddetectionofciliarybeatingpatternandfrequencyintheupperairwayusingphaseresolveddoppleropticalcoherencetomography AT zhongpingchen visualizationanddetectionofciliarybeatingpatternandfrequencyintheupperairwayusingphaseresolveddoppleropticalcoherencetomography
_version_	1718388622343798784

Visualization and Detection of Ciliary Beating Pattern and Frequency in the Upper Airway using Phase Resolved Doppler Optical Coherence Tomography

Ejemplares similares