A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.

Angiogenesis is a hallmark of tumor development and metastasis and now a validated target for cancer treatment. We previously reported that a novel dimer peptide (apoEdp) derived from the receptor binding region of human apolipoprotein E (apoE) inhibits virus-induced angiogenesis. However, its role...

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Autores principales:	Partha S Bhattacharjee, Tashfin S Huq, Tarun K Mandal, Richard A Graves, Syed Muniruzzaman, Christian Clement, Harris E McFerrin, James M Hill
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0435529784594d09a8ef39cc2d5295bc
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spelling	oai:doaj.org-article:0435529784594d09a8ef39cc2d5295bc2021-11-18T07:00:44ZA novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.1932-620310.1371/journal.pone.0015905https://doaj.org/article/0435529784594d09a8ef39cc2d5295bc2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21253017/?tool=EBIhttps://doaj.org/toc/1932-6203Angiogenesis is a hallmark of tumor development and metastasis and now a validated target for cancer treatment. We previously reported that a novel dimer peptide (apoEdp) derived from the receptor binding region of human apolipoprotein E (apoE) inhibits virus-induced angiogenesis. However, its role in tumor anti-angiogenesis is unknown. This study demonstrates that apoEdp has anti-angiogenic property in vivo through reduction of tumor growth in a mouse model and ocular angiogenesis in a rabbit eye model. Our in vitro studies show that apoEdp inhibits human umbilical vein endothelial cell proliferation, migration, invasion and capillary tube formation. We document that apoEdp inhibits vascular endothelial growth factor-induced Flk-1 activation as well as downstream signaling pathways that involve c-Src, Akt, eNOS, FAK, and ERK1/2. These in vitro data suggest potential sites of the apoE dipeptide inhibition that could occur in vivo.This is the first evidence that a synthetic dimer peptide mimicking human apoE has anti-angiogenesis functions and could be an anti-tumor drug candidate.Partha S BhattacharjeeTashfin S HuqTarun K MandalRichard A GravesSyed MuniruzzamanChristian ClementHarris E McFerrinJames M HillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 1, p e15905 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Partha S Bhattacharjee Tashfin S Huq Tarun K Mandal Richard A Graves Syed Muniruzzaman Christian Clement Harris E McFerrin James M Hill A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
description	Angiogenesis is a hallmark of tumor development and metastasis and now a validated target for cancer treatment. We previously reported that a novel dimer peptide (apoEdp) derived from the receptor binding region of human apolipoprotein E (apoE) inhibits virus-induced angiogenesis. However, its role in tumor anti-angiogenesis is unknown. This study demonstrates that apoEdp has anti-angiogenic property in vivo through reduction of tumor growth in a mouse model and ocular angiogenesis in a rabbit eye model. Our in vitro studies show that apoEdp inhibits human umbilical vein endothelial cell proliferation, migration, invasion and capillary tube formation. We document that apoEdp inhibits vascular endothelial growth factor-induced Flk-1 activation as well as downstream signaling pathways that involve c-Src, Akt, eNOS, FAK, and ERK1/2. These in vitro data suggest potential sites of the apoE dipeptide inhibition that could occur in vivo.This is the first evidence that a synthetic dimer peptide mimicking human apoE has anti-angiogenesis functions and could be an anti-tumor drug candidate.
format	article
author	Partha S Bhattacharjee Tashfin S Huq Tarun K Mandal Richard A Graves Syed Muniruzzaman Christian Clement Harris E McFerrin James M Hill
author_facet	Partha S Bhattacharjee Tashfin S Huq Tarun K Mandal Richard A Graves Syed Muniruzzaman Christian Clement Harris E McFerrin James M Hill
author_sort	Partha S Bhattacharjee
title	A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
title_short	A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
title_full	A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
title_fullStr	A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
title_full_unstemmed	A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.
title_sort	novel peptide derived from human apolipoprotein e is an inhibitor of tumor growth and ocular angiogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0435529784594d09a8ef39cc2d5295bc
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A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis.

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