Functional significance of U2AF1 S34F mutations in lung adenocarcinomas
The authors report a co-occurrence of the U2AF1 S34F splicing factor mutation and ROS1 translocations in lung adenocarcinomas and profile effects of S34F on transcriptome-wide RNA binding. They further show that U2AF1 S34F enhances invasive potential and alters splicing of ROS1 fusion transcripts
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Nature Portfolio
2019
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oai:doaj.org-article:0437a662c77043ed87f4f0be71eb3a882021-12-02T16:57:08ZFunctional significance of U2AF1 S34F mutations in lung adenocarcinomas10.1038/s41467-019-13392-y2041-1723https://doaj.org/article/0437a662c77043ed87f4f0be71eb3a882019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13392-yhttps://doaj.org/toc/2041-1723The authors report a co-occurrence of the U2AF1 S34F splicing factor mutation and ROS1 translocations in lung adenocarcinomas and profile effects of S34F on transcriptome-wide RNA binding. They further show that U2AF1 S34F enhances invasive potential and alters splicing of ROS1 fusion transcriptsMohammad S. EsfahaniLuke J. LeeYoung-Jun JeonRyan A. FlynnHenning StehrAngela B. HuiNoriko IshisokoEric KildebeckAaron M. NewmanScott V. BratmanMatthew H. PorteusHoward Y. ChangAsh A. AlizadehMaximilian DiehnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mohammad S. Esfahani Luke J. Lee Young-Jun Jeon Ryan A. Flynn Henning Stehr Angela B. Hui Noriko Ishisoko Eric Kildebeck Aaron M. Newman Scott V. Bratman Matthew H. Porteus Howard Y. Chang Ash A. Alizadeh Maximilian Diehn Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| description |
The authors report a co-occurrence of the U2AF1 S34F splicing factor mutation and ROS1 translocations in lung adenocarcinomas and profile effects of S34F on transcriptome-wide RNA binding. They further show that U2AF1 S34F enhances invasive potential and alters splicing of ROS1 fusion transcripts |
| format |
article |
| author |
Mohammad S. Esfahani Luke J. Lee Young-Jun Jeon Ryan A. Flynn Henning Stehr Angela B. Hui Noriko Ishisoko Eric Kildebeck Aaron M. Newman Scott V. Bratman Matthew H. Porteus Howard Y. Chang Ash A. Alizadeh Maximilian Diehn |
| author_facet |
Mohammad S. Esfahani Luke J. Lee Young-Jun Jeon Ryan A. Flynn Henning Stehr Angela B. Hui Noriko Ishisoko Eric Kildebeck Aaron M. Newman Scott V. Bratman Matthew H. Porteus Howard Y. Chang Ash A. Alizadeh Maximilian Diehn |
| author_sort |
Mohammad S. Esfahani |
| title |
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| title_short |
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| title_full |
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| title_fullStr |
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| title_full_unstemmed |
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas |
| title_sort |
functional significance of u2af1 s34f mutations in lung adenocarcinomas |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/0437a662c77043ed87f4f0be71eb3a88 |
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