Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit

The exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorde...

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Autores principales:	Morgane Boone, Pathmanaban Ramasamy, Jasper Zuallaert, Robbin Bouwmeester, Berre Van Moer, Davy Maddelein, Demet Turan, Niels Hulstaert, Hannah Eeckhaut, Elien Vandermarliere, Lennart Martens, Sven Degroeve, Wim De Neve, Wim Vranken, Nico Callewaert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/043a1799d9594a9ab4b4cd01c3c5aabe
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spelling	oai:doaj.org-article:043a1799d9594a9ab4b4cd01c3c5aabe2021-11-08T11:06:28ZMassively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit10.1038/s41467-021-26720-y2041-1723https://doaj.org/article/043a1799d9594a9ab4b4cd01c3c5aabe2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26720-yhttps://doaj.org/toc/2041-1723The exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorder.Morgane BoonePathmanaban RamasamyJasper ZuallaertRobbin BouwmeesterBerre Van MoerDavy MaddeleinDemet TuranNiels HulstaertHannah EeckhautElien VandermarliereLennart MartensSven DegroeveWim De NeveWim VrankenNico CallewaertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wim De Neve Wim Vranken Nico Callewaert Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
description	The exact protein features that control passage through the eukaryotic secretory system remain largely unknown. Here the authors report SECRiFY which they use to evaluate the secretory potential of polypeptides on a proteome-wide scale in yeast, revealing a role for flexibility and intrinsic disorder.
format	article
author	Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wim De Neve Wim Vranken Nico Callewaert
author_facet	Morgane Boone Pathmanaban Ramasamy Jasper Zuallaert Robbin Bouwmeester Berre Van Moer Davy Maddelein Demet Turan Niels Hulstaert Hannah Eeckhaut Elien Vandermarliere Lennart Martens Sven Degroeve Wim De Neve Wim Vranken Nico Callewaert
author_sort	Morgane Boone
title	Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
title_short	Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
title_full	Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
title_fullStr	Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
title_full_unstemmed	Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit
title_sort	massively parallel interrogation of protein fragment secretability using secrify reveals features influencing secretory system transit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/043a1799d9594a9ab4b4cd01c3c5aabe
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Massively parallel interrogation of protein fragment secretability using SECRiFY reveals features influencing secretory system transit

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