Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and show the utility of polygenic risk scores may vary depending...

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Autores principales:	Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F. Easton, Roger L. Milne, Jacques Simard, Per Hall, Kyriaki Michailidou, Joe Dennis, Marjanka K. Schmidt, Jenny Chang-Claude, Puya Gharahkhani, David Whiteman, Peter T. Campbell, Michael Hoffmeister, Mark Jenkins, Ulrike Peters, Li Hsu, Stephen B. Gruber, Graham Casey, Stephanie L. Schmit, Tracy A. O’Mara, Amanda B. Spurdle, Deborah J. Thompson, Ian Tomlinson, Immaculata De Vivo, Maria Teresa Landi, Matthew H. Law, Mark M. Iles, Florence Demenais, Rajiv Kumar, Stuart MacGregor, D. Timothy Bishop, Sarah V. Ward, Melissa L. Bondy, Richard Houlston, John K. Wiencke, Beatrice Melin, Jill Barnholtz-Sloan, Ben Kinnersley, Margaret R. Wrensch, Christopher I. Amos, Rayjean J. Hung, Paul Brennan, James McKay, Neil E. Caporaso, Sonja I. Berndt, Brenda M. Birmann, Nicola J. Camp, Peter Kraft, Nathaniel Rothman, Susan L. Slager, Andrew Berchuck, Paul D. P. Pharoah, Thomas A. Sellers, Simon A. Gayther, Celeste L. Pearce, Ellen L. Goode, Joellen M. Schildkraut, Kirsten B. Moysich, Laufey T. Amundadottir, Eric J. Jacobs, Alison P. Klein, Gloria M. Petersen, Harvey A. Risch, Rachel Z. Stolzenberg-Solomon, Brian M. Wolpin, Donghui Li, Rosalind A. Eeles, Christopher A. Haiman, Zsofia Kote-Jarai, Fredrick R. Schumacher, Ali Amin Al Olama, Mark P. Purdue, Ghislaine Scelo, Marlene D. Dalgaard, Mark H. Greene, Tom Grotmol, Peter A. Kanetsky, Katherine A. McGlynn, Katherine L. Nathanson, Clare Turnbull, Fredrik Wiklund, Breast Cancer Association Consortium (BCAC), Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON), Colon Cancer Family Registry (CCFR), Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT), Endometrial Cancer Association Consortium (ECAC), Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Melanoma Genetics Consortium (GenoMEL), Glioma International Case-Control Study (GICC), International Lung Cancer Consortium (ILCCO), Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium, International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph), Ovarian Cancer Association Consortium (OCAC), Oral Cancer GWAS, Pancreatic Cancer Case-Control Consortium (PanC4), Pancreatic Cancer Cohort Consortium (PanScan), Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL), Renal Cancer GWAS, Testicular Cancer Consortium (TECAC), Stephen J. Chanock, Nilanjan Chatterjee, Montserrat Garcia-Closas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/043bfd656ef148a0993f50953c04b25f
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spelling	oai:doaj.org-article:043bfd656ef148a0993f50953c04b25f2021-12-02T18:18:46ZAssessment of polygenic architecture and risk prediction based on common variants across fourteen cancers10.1038/s41467-020-16483-32041-1723https://doaj.org/article/043bfd656ef148a0993f50953c04b25f2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16483-3https://doaj.org/toc/2041-1723In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and show the utility of polygenic risk scores may vary depending on cancer type.Yan Dora ZhangAmber N. HursonHaoyu ZhangParichoy Pal ChoudhuryDouglas F. EastonRoger L. MilneJacques SimardPer HallKyriaki MichailidouJoe DennisMarjanka K. SchmidtJenny Chang-ClaudePuya GharahkhaniDavid WhitemanPeter T. CampbellMichael HoffmeisterMark JenkinsUlrike PetersLi HsuStephen B. GruberGraham CaseyStephanie L. SchmitTracy A. O’MaraAmanda B. SpurdleDeborah J. ThompsonIan TomlinsonImmaculata De VivoMaria Teresa LandiMatthew H. LawMark M. IlesFlorence DemenaisRajiv KumarStuart MacGregorD. Timothy BishopSarah V. WardMelissa L. BondyRichard HoulstonJohn K. WienckeBeatrice MelinJill Barnholtz-SloanBen KinnersleyMargaret R. WrenschChristopher I. AmosRayjean J. HungPaul BrennanJames McKayNeil E. CaporasoSonja I. BerndtBrenda M. BirmannNicola J. CampPeter KraftNathaniel RothmanSusan L. SlagerAndrew BerchuckPaul D. P. PharoahThomas A. SellersSimon A. GaytherCeleste L. PearceEllen L. GoodeJoellen M. SchildkrautKirsten B. MoysichLaufey T. AmundadottirEric J. JacobsAlison P. KleinGloria M. PetersenHarvey A. RischRachel Z. Stolzenberg-SolomonBrian M. WolpinDonghui LiRosalind A. EelesChristopher A. HaimanZsofia Kote-JaraiFredrick R. SchumacherAli Amin Al OlamaMark P. PurdueGhislaine SceloMarlene D. DalgaardMark H. GreeneTom GrotmolPeter A. KanetskyKatherine A. McGlynnKatherine L. NathansonClare TurnbullFredrik WiklundBreast Cancer Association Consortium (BCAC)Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)Colon Cancer Family Registry (CCFR)Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)Endometrial Cancer Association Consortium (ECAC)Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)Melanoma Genetics Consortium (GenoMEL)Glioma International Case-Control Study (GICC)International Lung Cancer Consortium (ILCCO)Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) ConsortiumInternational Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph)Ovarian Cancer Association Consortium (OCAC)Oral Cancer GWASPancreatic Cancer Case-Control Consortium (PanC4)Pancreatic Cancer Cohort Consortium (PanScan)Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL)Renal Cancer GWASTesticular Cancer Consortium (TECAC)Stephen J. ChanockNilanjan ChatterjeeMontserrat Garcia-ClosasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Dora Zhang Amber N. Hurson Haoyu Zhang Parichoy Pal Choudhury Douglas F. Easton Roger L. Milne Jacques Simard Per Hall Kyriaki Michailidou Joe Dennis Marjanka K. Schmidt Jenny Chang-Claude Puya Gharahkhani David Whiteman Peter T. Campbell Michael Hoffmeister Mark Jenkins Ulrike Peters Li Hsu Stephen B. Gruber Graham Casey Stephanie L. Schmit Tracy A. O’Mara Amanda B. Spurdle Deborah J. Thompson Ian Tomlinson Immaculata De Vivo Maria Teresa Landi Matthew H. Law Mark M. Iles Florence Demenais Rajiv Kumar Stuart MacGregor D. Timothy Bishop Sarah V. Ward Melissa L. Bondy Richard Houlston John K. Wiencke Beatrice Melin Jill Barnholtz-Sloan Ben Kinnersley Margaret R. Wrensch Christopher I. Amos Rayjean J. Hung Paul Brennan James McKay Neil E. Caporaso Sonja I. Berndt Brenda M. Birmann Nicola J. Camp Peter Kraft Nathaniel Rothman Susan L. Slager Andrew Berchuck Paul D. P. Pharoah Thomas A. Sellers Simon A. Gayther Celeste L. Pearce Ellen L. Goode Joellen M. Schildkraut Kirsten B. Moysich Laufey T. Amundadottir Eric J. Jacobs Alison P. Klein Gloria M. Petersen Harvey A. Risch Rachel Z. Stolzenberg-Solomon Brian M. Wolpin Donghui Li Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Ali Amin Al Olama Mark P. Purdue Ghislaine Scelo Marlene D. Dalgaard Mark H. Greene Tom Grotmol Peter A. Kanetsky Katherine A. McGlynn Katherine L. Nathanson Clare Turnbull Fredrik Wiklund Breast Cancer Association Consortium (BCAC) Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) Colon Cancer Family Registry (CCFR) Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT) Endometrial Cancer Association Consortium (ECAC) Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) Melanoma Genetics Consortium (GenoMEL) Glioma International Case-Control Study (GICC) International Lung Cancer Consortium (ILCCO) Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph) Ovarian Cancer Association Consortium (OCAC) Oral Cancer GWAS Pancreatic Cancer Case-Control Consortium (PanC4) Pancreatic Cancer Cohort Consortium (PanScan) Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Renal Cancer GWAS Testicular Cancer Consortium (TECAC) Stephen J. Chanock Nilanjan Chatterjee Montserrat Garcia-Closas Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
description	In cancer many gene variants may contribute to disease etiology, but the impact of a given gene variant may have varied effect size. Here, the authors analyse summary statistics of genome-wide association studies from fourteen cancers, and show the utility of polygenic risk scores may vary depending on cancer type.
format	article
author	Yan Dora Zhang Amber N. Hurson Haoyu Zhang Parichoy Pal Choudhury Douglas F. Easton Roger L. Milne Jacques Simard Per Hall Kyriaki Michailidou Joe Dennis Marjanka K. Schmidt Jenny Chang-Claude Puya Gharahkhani David Whiteman Peter T. Campbell Michael Hoffmeister Mark Jenkins Ulrike Peters Li Hsu Stephen B. Gruber Graham Casey Stephanie L. Schmit Tracy A. O’Mara Amanda B. Spurdle Deborah J. Thompson Ian Tomlinson Immaculata De Vivo Maria Teresa Landi Matthew H. Law Mark M. Iles Florence Demenais Rajiv Kumar Stuart MacGregor D. Timothy Bishop Sarah V. Ward Melissa L. Bondy Richard Houlston John K. Wiencke Beatrice Melin Jill Barnholtz-Sloan Ben Kinnersley Margaret R. Wrensch Christopher I. Amos Rayjean J. Hung Paul Brennan James McKay Neil E. Caporaso Sonja I. Berndt Brenda M. Birmann Nicola J. Camp Peter Kraft Nathaniel Rothman Susan L. Slager Andrew Berchuck Paul D. P. Pharoah Thomas A. Sellers Simon A. Gayther Celeste L. Pearce Ellen L. Goode Joellen M. Schildkraut Kirsten B. Moysich Laufey T. Amundadottir Eric J. Jacobs Alison P. Klein Gloria M. Petersen Harvey A. Risch Rachel Z. Stolzenberg-Solomon Brian M. Wolpin Donghui Li Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Ali Amin Al Olama Mark P. Purdue Ghislaine Scelo Marlene D. Dalgaard Mark H. Greene Tom Grotmol Peter A. Kanetsky Katherine A. McGlynn Katherine L. Nathanson Clare Turnbull Fredrik Wiklund Breast Cancer Association Consortium (BCAC) Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) Colon Cancer Family Registry (CCFR) Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT) Endometrial Cancer Association Consortium (ECAC) Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) Melanoma Genetics Consortium (GenoMEL) Glioma International Case-Control Study (GICC) International Lung Cancer Consortium (ILCCO) Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph) Ovarian Cancer Association Consortium (OCAC) Oral Cancer GWAS Pancreatic Cancer Case-Control Consortium (PanC4) Pancreatic Cancer Cohort Consortium (PanScan) Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Renal Cancer GWAS Testicular Cancer Consortium (TECAC) Stephen J. Chanock Nilanjan Chatterjee Montserrat Garcia-Closas
author_facet	Yan Dora Zhang Amber N. Hurson Haoyu Zhang Parichoy Pal Choudhury Douglas F. Easton Roger L. Milne Jacques Simard Per Hall Kyriaki Michailidou Joe Dennis Marjanka K. Schmidt Jenny Chang-Claude Puya Gharahkhani David Whiteman Peter T. Campbell Michael Hoffmeister Mark Jenkins Ulrike Peters Li Hsu Stephen B. Gruber Graham Casey Stephanie L. Schmit Tracy A. O’Mara Amanda B. Spurdle Deborah J. Thompson Ian Tomlinson Immaculata De Vivo Maria Teresa Landi Matthew H. Law Mark M. Iles Florence Demenais Rajiv Kumar Stuart MacGregor D. Timothy Bishop Sarah V. Ward Melissa L. Bondy Richard Houlston John K. Wiencke Beatrice Melin Jill Barnholtz-Sloan Ben Kinnersley Margaret R. Wrensch Christopher I. Amos Rayjean J. Hung Paul Brennan James McKay Neil E. Caporaso Sonja I. Berndt Brenda M. Birmann Nicola J. Camp Peter Kraft Nathaniel Rothman Susan L. Slager Andrew Berchuck Paul D. P. Pharoah Thomas A. Sellers Simon A. Gayther Celeste L. Pearce Ellen L. Goode Joellen M. Schildkraut Kirsten B. Moysich Laufey T. Amundadottir Eric J. Jacobs Alison P. Klein Gloria M. Petersen Harvey A. Risch Rachel Z. Stolzenberg-Solomon Brian M. Wolpin Donghui Li Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Ali Amin Al Olama Mark P. Purdue Ghislaine Scelo Marlene D. Dalgaard Mark H. Greene Tom Grotmol Peter A. Kanetsky Katherine A. McGlynn Katherine L. Nathanson Clare Turnbull Fredrik Wiklund Breast Cancer Association Consortium (BCAC) Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON) Colon Cancer Family Registry (CCFR) Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT) Endometrial Cancer Association Consortium (ECAC) Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) Melanoma Genetics Consortium (GenoMEL) Glioma International Case-Control Study (GICC) International Lung Cancer Consortium (ILCCO) Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph) Ovarian Cancer Association Consortium (OCAC) Oral Cancer GWAS Pancreatic Cancer Case-Control Consortium (PanC4) Pancreatic Cancer Cohort Consortium (PanScan) Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) Renal Cancer GWAS Testicular Cancer Consortium (TECAC) Stephen J. Chanock Nilanjan Chatterjee Montserrat Garcia-Closas
author_sort	Yan Dora Zhang
title	Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
title_short	Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
title_full	Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
title_fullStr	Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
title_full_unstemmed	Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
title_sort	assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/043bfd656ef148a0993f50953c04b25f
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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

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