Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.

<h4>Context</h4>Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents.<h4>Objective</h4>To evaluate the association between telomere lengt...

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Autores principales:	Sonia García-Calzón, Adriana Moleres, Ascensión Marcos, Cristina Campoy, Luis A Moreno, M Cristina Azcona-Sanjulián, Miguel A Martínez-González, J Alfredo Martínez, Guillermo Zalba, Amelia Marti, EVASYON Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/043c51a83b2e4d4fa9b655473a57a961
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spelling	oai:doaj.org-article:043c51a83b2e4d4fa9b655473a57a9612021-11-18T08:31:15ZTelomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.1932-620310.1371/journal.pone.0089828https://doaj.org/article/043c51a83b2e4d4fa9b655473a57a9612014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587065/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents.<h4>Objective</h4>To evaluate the association between telomere length (TL) and adiposity markers in overweight/obese adolescents after an intensive program. We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment.<h4>Design setting patients and intervention</h4>The EVASYON is a multidisciplinary treatment program for adolescents with overweight and obesity that is aimed at applying the intervention to all possibly involved areas of the individual, such as dietary habits, physical activity and cognitive and psychological profiles. Seventy-four participants (36 males, 38 females, 12-16 yr) were enrolled in the intervention program: 2 months of an energy-restricted diet and a follow-up period (6 months).<h4>Main outcome</h4>TL was measured by quantitative real-time polymerase chain reaction at baseline and after 2 months; meanwhile, anthropometric variables were also assessed after 6 months of follow-up.<h4>Results</h4>TL lengthened in participants during the intensive period (+1.9±1.0, p<0.001) being greater in overweight/obese adolescents with the shortest telomeres at baseline (r = -0.962, p<0.001). Multivariable linear regression analysis showed that higher baseline TL significantly predicted a higher decrease in body weight (B = -1.53, p = 0.005; B = -2.25, p = 0.047) and in standard deviation score for body mass index (BMI-SDS) (B = -0.22, p = 0.010; B = -0.47, p = 0.005) after the intensive and extensive period treatment respectively, in boys.<h4>Conclusion</h4>Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight/obese adolescents. Moreover, we suggest that initial longer TL could be a potential predictor for a better weight loss response.Sonia García-CalzónAdriana MoleresAscensión MarcosCristina CampoyLuis A MorenoM Cristina Azcona-SanjuliánMiguel A Martínez-GonzálezJ Alfredo MartínezGuillermo ZalbaAmelia MartiEVASYON Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89828 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonia García-Calzón Adriana Moleres Ascensión Marcos Cristina Campoy Luis A Moreno M Cristina Azcona-Sanjulián Miguel A Martínez-González J Alfredo Martínez Guillermo Zalba Amelia Marti EVASYON Study Group Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
description	<h4>Context</h4>Telomeres are biomarkers of biological aging. Shorter telomeres have been associated with increased adiposity in adults. However, this relationship remains unclear in children and adolescents.<h4>Objective</h4>To evaluate the association between telomere length (TL) and adiposity markers in overweight/obese adolescents after an intensive program. We hypothesize that greater TL at baseline would predict a better response to a weight loss treatment.<h4>Design setting patients and intervention</h4>The EVASYON is a multidisciplinary treatment program for adolescents with overweight and obesity that is aimed at applying the intervention to all possibly involved areas of the individual, such as dietary habits, physical activity and cognitive and psychological profiles. Seventy-four participants (36 males, 38 females, 12-16 yr) were enrolled in the intervention program: 2 months of an energy-restricted diet and a follow-up period (6 months).<h4>Main outcome</h4>TL was measured by quantitative real-time polymerase chain reaction at baseline and after 2 months; meanwhile, anthropometric variables were also assessed after 6 months of follow-up.<h4>Results</h4>TL lengthened in participants during the intensive period (+1.9±1.0, p<0.001) being greater in overweight/obese adolescents with the shortest telomeres at baseline (r = -0.962, p<0.001). Multivariable linear regression analysis showed that higher baseline TL significantly predicted a higher decrease in body weight (B = -1.53, p = 0.005; B = -2.25, p = 0.047) and in standard deviation score for body mass index (BMI-SDS) (B = -0.22, p = 0.010; B = -0.47, p = 0.005) after the intensive and extensive period treatment respectively, in boys.<h4>Conclusion</h4>Our study shows that a weight loss intervention is accompanied by a significant increase in TL in overweight/obese adolescents. Moreover, we suggest that initial longer TL could be a potential predictor for a better weight loss response.
format	article
author	Sonia García-Calzón Adriana Moleres Ascensión Marcos Cristina Campoy Luis A Moreno M Cristina Azcona-Sanjulián Miguel A Martínez-González J Alfredo Martínez Guillermo Zalba Amelia Marti EVASYON Study Group
author_facet	Sonia García-Calzón Adriana Moleres Ascensión Marcos Cristina Campoy Luis A Moreno M Cristina Azcona-Sanjulián Miguel A Martínez-González J Alfredo Martínez Guillermo Zalba Amelia Marti EVASYON Study Group
author_sort	Sonia García-Calzón
title	Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
title_short	Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
title_full	Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
title_fullStr	Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
title_full_unstemmed	Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.
title_sort	telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the evasyon study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/043c51a83b2e4d4fa9b655473a57a961
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Telomere length as a biomarker for adiposity changes after a multidisciplinary intervention in overweight/obese adolescents: the EVASYON study.

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