Exercise-induced changes in stress hormones and cell adhesion molecules in obese men

Jinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Park J, Willoughby DS, Song JJ, Leutholtz BC, Koh Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Vascular inflammation ICAM-1 VACM-1 E-selectin Stress hormones Exercise intensity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/043ebb1a166542e59078188528c6080e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:043ebb1a166542e59078188528c6080e
record_format	dspace
spelling	oai:doaj.org-article:043ebb1a166542e59078188528c6080e2021-12-02T01:43:45ZExercise-induced changes in stress hormones and cell adhesion molecules in obese men1178-7031https://doaj.org/article/043ebb1a166542e59078188528c6080e2018-03-01T00:00:00Zhttps://www.dovepress.com/exercise-induced-changes-in-stress-hormones-and-cell-adhesion-molecule-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University, Waco, TX, USA Purpose: The current study examined the relationship between exercise-induced changes in stress hormones (epinephrine, norepinephrine, and cortisol) and vascular inflammatory markers (soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial selectin [sE-selectin], and soluble vascular adhesion molecule-1 [sVCAM-1]) in obese men over a 24-hour period following exercise at lower and higher intensity.Patients and methods: Fifteen physically inactive, obese, college-aged men performed a single bout of cycling exercise at lower and higher intensities (lower intensity: 50% of maximal heart rate, and higher intensity: 80% of maximal heart rate) in random order. Overnight fasting blood samples were collected at baseline, immediately postexercise (IPE), 1-hour PE (1-h PE), and 24-hour PE. Changes in stress hormones and inflammatory markers were analyzed with a repeated-measures analysis of variance using Bonferroni multiple comparisons and a linear regression analysis (p<0.05).Results: sICAM-1, sVCAM-1, epinephrine, and norepinephrine did not change over time, while sE-selectin was significantly lower at 1-h PE (10.25±1.07 ng/mL, p=0.04) than at baseline (12.22±1.39 ng/mL). Cortisol and sICAM-1 were negatively related at 1-h PE following lower-intensity exercise (r2=0.34, p=0.02), whereas cortisol and sVCAM-1 were positively related at IPE following higher-intensity exercise (r2=0.36, p=0.02).Conclusion: Regardless of intensity, an acute bout of aerobic exercise may lower sE-selectin in sedentary obese men. Responses of cortisol are dependent on exercise intensity, and cortisol may be a key stress hormone playing a major role in regulating sICAM-1 and sVCAM-1. Keywords: vascular inflammation, ICAM-1, VACM-1, E-selectin, stress hormones, exercise intensityPark JWilloughby DSSong JJLeutholtz BCKoh YDove Medical PressarticleVascular inflammationICAM-1VACM-1E-selectinStress hormonesExercise intensityPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 69-75 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Vascular inflammation ICAM-1 VACM-1 E-selectin Stress hormones Exercise intensity Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Vascular inflammation ICAM-1 VACM-1 E-selectin Stress hormones Exercise intensity Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Park J Willoughby DS Song JJ Leutholtz BC Koh Y Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
description	Jinkyung Park,1 Darryn S Willoughby,2 Joon Jin Song,3 Brian C Leutholtz,2 Yunsuk Koh2 1Department of Kinesiology, George Mason University, Manassas, VA, USA; 2Department of Health, Human Performance, Recreation, Baylor University, Waco, TX, USA; 3Department of Statistical Science, Baylor University, Waco, TX, USA Purpose: The current study examined the relationship between exercise-induced changes in stress hormones (epinephrine, norepinephrine, and cortisol) and vascular inflammatory markers (soluble intracellular adhesion molecule-1 [sICAM-1], soluble endothelial selectin [sE-selectin], and soluble vascular adhesion molecule-1 [sVCAM-1]) in obese men over a 24-hour period following exercise at lower and higher intensity.Patients and methods: Fifteen physically inactive, obese, college-aged men performed a single bout of cycling exercise at lower and higher intensities (lower intensity: 50% of maximal heart rate, and higher intensity: 80% of maximal heart rate) in random order. Overnight fasting blood samples were collected at baseline, immediately postexercise (IPE), 1-hour PE (1-h PE), and 24-hour PE. Changes in stress hormones and inflammatory markers were analyzed with a repeated-measures analysis of variance using Bonferroni multiple comparisons and a linear regression analysis (p<0.05).Results: sICAM-1, sVCAM-1, epinephrine, and norepinephrine did not change over time, while sE-selectin was significantly lower at 1-h PE (10.25±1.07 ng/mL, p=0.04) than at baseline (12.22±1.39 ng/mL). Cortisol and sICAM-1 were negatively related at 1-h PE following lower-intensity exercise (r2=0.34, p=0.02), whereas cortisol and sVCAM-1 were positively related at IPE following higher-intensity exercise (r2=0.36, p=0.02).Conclusion: Regardless of intensity, an acute bout of aerobic exercise may lower sE-selectin in sedentary obese men. Responses of cortisol are dependent on exercise intensity, and cortisol may be a key stress hormone playing a major role in regulating sICAM-1 and sVCAM-1. Keywords: vascular inflammation, ICAM-1, VACM-1, E-selectin, stress hormones, exercise intensity
format	article
author	Park J Willoughby DS Song JJ Leutholtz BC Koh Y
author_facet	Park J Willoughby DS Song JJ Leutholtz BC Koh Y
author_sort	Park J
title	Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
title_short	Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
title_full	Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
title_fullStr	Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
title_full_unstemmed	Exercise-induced changes in stress hormones and cell adhesion molecules in obese men
title_sort	exercise-induced changes in stress hormones and cell adhesion molecules in obese men
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/043ebb1a166542e59078188528c6080e
work_keys_str_mv	AT parkj exerciseinducedchangesinstresshormonesandcelladhesionmoleculesinobesemen AT willoughbyds exerciseinducedchangesinstresshormonesandcelladhesionmoleculesinobesemen AT songjj exerciseinducedchangesinstresshormonesandcelladhesionmoleculesinobesemen AT leutholtzbc exerciseinducedchangesinstresshormonesandcelladhesionmoleculesinobesemen AT kohy exerciseinducedchangesinstresshormonesandcelladhesionmoleculesinobesemen
_version_	1718402878905778176

Exercise-induced changes in stress hormones and cell adhesion molecules in obese men

Ejemplares similares