Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments

The mecA gene confers resistance to many β-lactam antibiotics in community-associated MRSA bacteria. Here, Snitser et al. show that mecA also provides broad selective advantage across diverse chemical environments in the presence of subinhibitory β-lactam concentrations, by protecting the bacteria a...

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Autores principales: Olga Snitser, Dor Russ, Laura K. Stone, Kathy K. Wang, Haleli Sharir, Noga Kozer, Galit Cohen, Haim M. Barr, Roy Kishony
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/04489c0e58f44ad5af07b868ae9d4e8d
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Sumario:The mecA gene confers resistance to many β-lactam antibiotics in community-associated MRSA bacteria. Here, Snitser et al. show that mecA also provides broad selective advantage across diverse chemical environments in the presence of subinhibitory β-lactam concentrations, by protecting the bacteria against increased cell-envelope permeability.