A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration

Abstract Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This dysfunction is a result of neurodegeneration within the olfactory bulb (OB), the first processing area of the central olfactory system, and commonly precedes the characteristic motor symptoms in PD by s...

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Autores principales:	Behzad Iravani, Artin Arshamian, Martin Schaefer, Per Svenningsson, Johan N. Lundström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0448c577e4684735b259ac99660648af
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spelling	oai:doaj.org-article:0448c577e4684735b259ac99660648af2021-12-02T15:10:40ZA non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration10.1038/s41531-021-00220-82373-8057https://doaj.org/article/0448c577e4684735b259ac99660648af2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00220-8https://doaj.org/toc/2373-8057Abstract Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This dysfunction is a result of neurodegeneration within the olfactory bulb (OB), the first processing area of the central olfactory system, and commonly precedes the characteristic motor symptoms in PD by several years. Functional measurements of the OB could therefore potentially be used as an early biomarker for PD. Here, we used a non-invasive method, so-called electrobulbogram (EBG), to measure OB function in PD and age-matched healthy controls to assess whether EBG measures can dissociate PDs from controls. We estimated the spectrogram of the EBG signal during exposure to odor in PD (n = 20) and age-matched controls (n = 18) as well as identified differentiating patterns of odor-related synchronization in the gamma, beta, and theta frequency bands. Moreover, we assessed if these PD-EBG components could dissociate PD from control as well as their relationship with PD characteristics. We identified six EBG components during the initial and later stages of odor processing which dissociated PD from controls with 90% sensitivity and 100% specificity with links to PD characteristics. These PD-EBG components were related to medication, disease duration, and severity, as well as clinical odor identification performance. These findings support using EBG as a tool to experimentally assess PD interventions, potentially aid diagnosis, and the potential development of EBG into an early biomarker for PD.Behzad IravaniArtin ArshamianMartin SchaeferPer SvenningssonJohan N. LundströmNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Behzad Iravani Artin Arshamian Martin Schaefer Per Svenningsson Johan N. Lundström A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
description	Abstract Olfactory dysfunction is a prevalent non-motor symptom of Parkinson’s disease (PD). This dysfunction is a result of neurodegeneration within the olfactory bulb (OB), the first processing area of the central olfactory system, and commonly precedes the characteristic motor symptoms in PD by several years. Functional measurements of the OB could therefore potentially be used as an early biomarker for PD. Here, we used a non-invasive method, so-called electrobulbogram (EBG), to measure OB function in PD and age-matched healthy controls to assess whether EBG measures can dissociate PDs from controls. We estimated the spectrogram of the EBG signal during exposure to odor in PD (n = 20) and age-matched controls (n = 18) as well as identified differentiating patterns of odor-related synchronization in the gamma, beta, and theta frequency bands. Moreover, we assessed if these PD-EBG components could dissociate PD from control as well as their relationship with PD characteristics. We identified six EBG components during the initial and later stages of odor processing which dissociated PD from controls with 90% sensitivity and 100% specificity with links to PD characteristics. These PD-EBG components were related to medication, disease duration, and severity, as well as clinical odor identification performance. These findings support using EBG as a tool to experimentally assess PD interventions, potentially aid diagnosis, and the potential development of EBG into an early biomarker for PD.
format	article
author	Behzad Iravani Artin Arshamian Martin Schaefer Per Svenningsson Johan N. Lundström
author_facet	Behzad Iravani Artin Arshamian Martin Schaefer Per Svenningsson Johan N. Lundström
author_sort	Behzad Iravani
title	A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
title_short	A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
title_full	A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
title_fullStr	A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
title_full_unstemmed	A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration
title_sort	non-invasive olfactory bulb measure dissociates parkinson’s patients from healthy controls and discloses disease duration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0448c577e4684735b259ac99660648af
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A non-invasive olfactory bulb measure dissociates Parkinson’s patients from healthy controls and discloses disease duration

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