Thyroid Hormone Changes in Euthyroid Patients with Diabetes

Ken Qin,1,* Fan Zhang,1,* Qinqin Wu,1 Zhenrong Liu,1 Yan Huang,1 Jing Tan,2 Yiling Zhou,3 Zhenmei An,3 Shuangqing Li,4 Sheyu Li3,5,6 1Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 2Chinese Evidence-Based Medicine Center CR...

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Autores principales:	Qin K, Zhang F, Wu Q, Liu Z, Huang Y, Tan J, Zhou Y, An Z, Li S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes mellitus thyroid hormones triiodothyronine thyroxine Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/04495699ef2e499f81eb5b07db4b313b
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spelling	oai:doaj.org-article:04495699ef2e499f81eb5b07db4b313b2021-12-02T10:33:52ZThyroid Hormone Changes in Euthyroid Patients with Diabetes1178-7007https://doaj.org/article/04495699ef2e499f81eb5b07db4b313b2020-07-01T00:00:00Zhttps://www.dovepress.com/thyroid-hormone-changes-in-euthyroid-patients-with-diabetes-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ken Qin,1,* Fan Zhang,1,* Qinqin Wu,1 Zhenrong Liu,1 Yan Huang,1 Jing Tan,2 Yiling Zhou,3 Zhenmei An,3 Shuangqing Li,4 Sheyu Li3,5,6 1Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 2Chinese Evidence-Based Medicine Center CREAT Group, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 3Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 4General Medical Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 5Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 6Engineering Research Center for Medical Information Technology, Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheyu LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 13194874843Email lisheyu@gmail.comShuangqing LiGeneral Medical Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 18980601354Email 1259594471@qq.comBackground: Thyroid dysfunction is associated with diabetes, but it is unclear if the thyroid hormone levels change in euthyroid adults with diabetes.Objective: To investigate the association between thyroid hormone levels and diabetes in euthyroid adults.Methods: Among the euthyroid adults who underwent health examination in West China Hospital of Sichuan University in 2016, patients with diabetes were identified according to the medical history, fasting blood glucose and HbA1c. Age and sex matched controls were identified from the population. The patients with diabetes group was further divided into two subgroups: patients with newly diagnosed diabetes (NDD) and with previously diagnosed diabetes (PDD). Independent t-test and multivariate logistic regression models were used to investigate the difference in the levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and the ratio of FT4/FT3 between groups.Results: We included 32,557 participants, 2,271 with diabetes. Compared to the adults without diabetes, the odds ratios (ORs) per one unit elevation of TSH, FT4, FT4/FT3 ratio and FT3 in patients with diabetes were 0.88 [95% confidence interval (CI): 0.82– 0.95], 1.11 (95% CI: 1.08– 1.14), 2.05 (95% CI: 1.81– 2.32) and 0.85 (95% CI: 0.78– 0.93), respectively. Compared to the NDD group, the ORs per one unit elevation of TSH, FT4, FT4/FT3 ratio and FT3 of the PDD group were 0.81 (95% CI: 0.71– 0.92), 1.08 (95% CI: 1.04– 1.12), 1.76 (95% CI: 1.49– 2.08) and 1.01 (95% CI: 0.92– 1.12), respectively.Conclusion: In euthyroid adults, diabetes was associated with increased FT4/FT3 ratio, which is linked to the peripheral turnover of the thyroid hormones.Keywords: diabetes mellitus, thyroid hormones, triiodothyronine, thyroxineQin KZhang FWu QLiu ZHuang YTan JZhou YAn ZLi SLi SDove Medical Pressarticlediabetes mellitusthyroid hormonestriiodothyroninethyroxineSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2533-2540 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus thyroid hormones triiodothyronine thyroxine Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus thyroid hormones triiodothyronine thyroxine Specialties of internal medicine RC581-951 Qin K Zhang F Wu Q Liu Z Huang Y Tan J Zhou Y An Z Li S Li S Thyroid Hormone Changes in Euthyroid Patients with Diabetes
description	Ken Qin,1,* Fan Zhang,1,* Qinqin Wu,1 Zhenrong Liu,1 Yan Huang,1 Jing Tan,2 Yiling Zhou,3 Zhenmei An,3 Shuangqing Li,4 Sheyu Li3,5,6 1Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 2Chinese Evidence-Based Medicine Center CREAT Group, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 3Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 4General Medical Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 5Chinese Evidence-Based Medicine Center, Cochrane China Center and MAGIC China Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of China; 6Engineering Research Center for Medical Information Technology, Ministry of Education, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheyu LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 13194874843Email lisheyu@gmail.comShuangqing LiGeneral Medical Center, West China Hospital, Sichuan University, Chengdu 610041, People’s Republic of ChinaTel +86 18980601354Email 1259594471@qq.comBackground: Thyroid dysfunction is associated with diabetes, but it is unclear if the thyroid hormone levels change in euthyroid adults with diabetes.Objective: To investigate the association between thyroid hormone levels and diabetes in euthyroid adults.Methods: Among the euthyroid adults who underwent health examination in West China Hospital of Sichuan University in 2016, patients with diabetes were identified according to the medical history, fasting blood glucose and HbA1c. Age and sex matched controls were identified from the population. The patients with diabetes group was further divided into two subgroups: patients with newly diagnosed diabetes (NDD) and with previously diagnosed diabetes (PDD). Independent t-test and multivariate logistic regression models were used to investigate the difference in the levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and the ratio of FT4/FT3 between groups.Results: We included 32,557 participants, 2,271 with diabetes. Compared to the adults without diabetes, the odds ratios (ORs) per one unit elevation of TSH, FT4, FT4/FT3 ratio and FT3 in patients with diabetes were 0.88 [95% confidence interval (CI): 0.82– 0.95], 1.11 (95% CI: 1.08– 1.14), 2.05 (95% CI: 1.81– 2.32) and 0.85 (95% CI: 0.78– 0.93), respectively. Compared to the NDD group, the ORs per one unit elevation of TSH, FT4, FT4/FT3 ratio and FT3 of the PDD group were 0.81 (95% CI: 0.71– 0.92), 1.08 (95% CI: 1.04– 1.12), 1.76 (95% CI: 1.49– 2.08) and 1.01 (95% CI: 0.92– 1.12), respectively.Conclusion: In euthyroid adults, diabetes was associated with increased FT4/FT3 ratio, which is linked to the peripheral turnover of the thyroid hormones.Keywords: diabetes mellitus, thyroid hormones, triiodothyronine, thyroxine
format	article
author	Qin K Zhang F Wu Q Liu Z Huang Y Tan J Zhou Y An Z Li S Li S
author_facet	Qin K Zhang F Wu Q Liu Z Huang Y Tan J Zhou Y An Z Li S Li S
author_sort	Qin K
title	Thyroid Hormone Changes in Euthyroid Patients with Diabetes
title_short	Thyroid Hormone Changes in Euthyroid Patients with Diabetes
title_full	Thyroid Hormone Changes in Euthyroid Patients with Diabetes
title_fullStr	Thyroid Hormone Changes in Euthyroid Patients with Diabetes
title_full_unstemmed	Thyroid Hormone Changes in Euthyroid Patients with Diabetes
title_sort	thyroid hormone changes in euthyroid patients with diabetes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/04495699ef2e499f81eb5b07db4b313b
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Thyroid Hormone Changes in Euthyroid Patients with Diabetes

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