Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.

Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several...

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Autores principales:	Kim M Gerecke, Yun Jiao, Viswajeeth Pagala, Richard J Smeyne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0449733c00204627974b8a39b8876ad2
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spelling	oai:doaj.org-article:0449733c00204627974b8a39b8876ad22021-11-18T07:08:25ZExercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.1932-620310.1371/journal.pone.0043250https://doaj.org/article/0449733c00204627974b8a39b8876ad22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22912838/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several neurotrophic factors, including Brain Derived Neurotrophic Factor (BDNF), have been shown to upregulate in response to exercise. In order to determine if exercise-induced neuroprotection is dependent upon BDNF, we compared the neuroprotective effects of voluntary exercise in mice heterozygous for the BDNF gene (BDNF+/-) with strain-matched wild-type (WT) mice. Stereological estimates of SNpc DA neurons from WT mice allowed 90 days exercise via unrestricted running demonstrated complete protection against the MPTP-induced neurotoxicity. However, BDNF+/- mice allowed 90 days of unrestricted exercise were not protected from MPTP-induced SNpc DA neuron loss. Proteomic analysis comparing SN and striatum from 90 day exercised WT and BDNF+/- mice showed differential expression of proteins related to energy regulation, intracellular signaling and trafficking. These results suggest that a full genetic complement of BDNF is critical for the exercise-induced neuroprotection of SNpc DA neurons.Kim M GereckeYun JiaoViswajeeth PagalaRichard J SmeynePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43250 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim M Gerecke Yun Jiao Viswajeeth Pagala Richard J Smeyne Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
description	Exercise has been demonstrated to potently protect substantia nigra pars compacta (SN) dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. One mechanism proposed to account for this neuroprotection is the upregulation of neurotrophic factors. Several neurotrophic factors, including Brain Derived Neurotrophic Factor (BDNF), have been shown to upregulate in response to exercise. In order to determine if exercise-induced neuroprotection is dependent upon BDNF, we compared the neuroprotective effects of voluntary exercise in mice heterozygous for the BDNF gene (BDNF+/-) with strain-matched wild-type (WT) mice. Stereological estimates of SNpc DA neurons from WT mice allowed 90 days exercise via unrestricted running demonstrated complete protection against the MPTP-induced neurotoxicity. However, BDNF+/- mice allowed 90 days of unrestricted exercise were not protected from MPTP-induced SNpc DA neuron loss. Proteomic analysis comparing SN and striatum from 90 day exercised WT and BDNF+/- mice showed differential expression of proteins related to energy regulation, intracellular signaling and trafficking. These results suggest that a full genetic complement of BDNF is critical for the exercise-induced neuroprotection of SNpc DA neurons.
format	article
author	Kim M Gerecke Yun Jiao Viswajeeth Pagala Richard J Smeyne
author_facet	Kim M Gerecke Yun Jiao Viswajeeth Pagala Richard J Smeyne
author_sort	Kim M Gerecke
title	Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
title_short	Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
title_full	Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
title_fullStr	Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
title_full_unstemmed	Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
title_sort	exercise does not protect against mptp-induced neurotoxicity in bdnf haploinsufficient mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0449733c00204627974b8a39b8876ad2
work_keys_str_mv	AT kimmgerecke exercisedoesnotprotectagainstmptpinducedneurotoxicityinbdnfhaploinsufficientmice AT yunjiao exercisedoesnotprotectagainstmptpinducedneurotoxicityinbdnfhaploinsufficientmice AT viswajeethpagala exercisedoesnotprotectagainstmptpinducedneurotoxicityinbdnfhaploinsufficientmice AT richardjsmeyne exercisedoesnotprotectagainstmptpinducedneurotoxicityinbdnfhaploinsufficientmice
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Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.

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