Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography

Abstract Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry that reveals the local direction of blood flow with...

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Autores principales:	Léo Puyo, Michel Paques, Michael Atlan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/044abb7f581c4985bc71cc6441ed2b6a
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spelling	oai:doaj.org-article:044abb7f581c4985bc71cc6441ed2b6a2021-12-02T19:12:33ZRetinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography10.1038/s41598-021-96877-52045-2322https://doaj.org/article/044abb7f581c4985bc71cc6441ed2b6a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96877-5https://doaj.org/toc/2045-2322Abstract Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry that reveals the local direction of blood flow with respect to the optical axis in out-of-plane vessels. This directional information is overlaid on standard grayscale blood flow images to depict flow moving towards the camera in red and flow moving away from the camera in blue, as in ultrasound color Doppler imaging. We show that thanks to the strong contribution of backscattering to the Doppler spectrum in out-of-plane vessels, the local axial direction of blood flow can be revealed with a high temporal resolution, which enables us to evidence pathological blood flow reversals. We also demonstrate the use of optical Doppler spectrograms to quantitatively monitor retinal blood flow reversals.Léo PuyoMichel PaquesMichael AtlanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Léo Puyo Michel Paques Michael Atlan Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
description	Abstract Laser Doppler holography is a planar blood flow imaging technique recently introduced in ophthalmology to image human retinal and choroidal blood flow non-invasively. Here we present a digital method based on the Doppler spectrum asymmetry that reveals the local direction of blood flow with respect to the optical axis in out-of-plane vessels. This directional information is overlaid on standard grayscale blood flow images to depict flow moving towards the camera in red and flow moving away from the camera in blue, as in ultrasound color Doppler imaging. We show that thanks to the strong contribution of backscattering to the Doppler spectrum in out-of-plane vessels, the local axial direction of blood flow can be revealed with a high temporal resolution, which enables us to evidence pathological blood flow reversals. We also demonstrate the use of optical Doppler spectrograms to quantitatively monitor retinal blood flow reversals.
format	article
author	Léo Puyo Michel Paques Michael Atlan
author_facet	Léo Puyo Michel Paques Michael Atlan
author_sort	Léo Puyo
title	Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
title_short	Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
title_full	Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
title_fullStr	Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
title_full_unstemmed	Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography
title_sort	retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser doppler holography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/044abb7f581c4985bc71cc6441ed2b6a
work_keys_str_mv	AT leopuyo retinalbloodflowreversalquantitativelymonitoredinoutofplanevesselswithlaserdopplerholography AT michelpaques retinalbloodflowreversalquantitativelymonitoredinoutofplanevesselswithlaserdopplerholography AT michaelatlan retinalbloodflowreversalquantitativelymonitoredinoutofplanevesselswithlaserdopplerholography
_version_	1718377035321049088

Retinal blood flow reversal quantitatively monitored in out-of-plane vessels with laser Doppler holography

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