Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

Sukhvir Wright et al. present a NMDAR antibody-induced model of encephalitis in rats and use in vitro, in vivo, and in silico electrophysiology to examine alterations in neural circuit behavior. Their results suggest that reduction of NMDARs leads to increased excitability and seizure activity, and...

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Autores principales:	Sukhvir K. Wright, Richard E. Rosch, Max A. Wilson, Manoj A. Upadhya, Divya R. Dhangar, Charlie Clarke-Bland, Tamara T. Wahid, Sumanta Barman, Norbert Goebels, Jakob Kreye, Harald Prüss, Leslie Jacobson, Danielle S. Bassett, Angela Vincent, Stuart D. Greenhill, Gavin L. Woodhall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/044abfeed3bf450a87ab1e4b273bc087
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spelling	oai:doaj.org-article:044abfeed3bf450a87ab1e4b273bc0872021-12-02T17:26:55ZMultimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis10.1038/s42003-021-02635-82399-3642https://doaj.org/article/044abfeed3bf450a87ab1e4b273bc0872021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02635-8https://doaj.org/toc/2399-3642Sukhvir Wright et al. present a NMDAR antibody-induced model of encephalitis in rats and use in vitro, in vivo, and in silico electrophysiology to examine alterations in neural circuit behavior. Their results suggest that reduction of NMDARs leads to increased excitability and seizure activity, and highlights the potential use of receptor-specific treatments in antibody-mediated seizures and epilepsy.Sukhvir K. WrightRichard E. RoschMax A. WilsonManoj A. UpadhyaDivya R. DhangarCharlie Clarke-BlandTamara T. WahidSumanta BarmanNorbert GoebelsJakob KreyeHarald PrüssLeslie JacobsonDanielle S. BassettAngela VincentStuart D. GreenhillGavin L. WoodhallNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sukhvir K. Wright Richard E. Rosch Max A. Wilson Manoj A. Upadhya Divya R. Dhangar Charlie Clarke-Bland Tamara T. Wahid Sumanta Barman Norbert Goebels Jakob Kreye Harald Prüss Leslie Jacobson Danielle S. Bassett Angela Vincent Stuart D. Greenhill Gavin L. Woodhall Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
description	Sukhvir Wright et al. present a NMDAR antibody-induced model of encephalitis in rats and use in vitro, in vivo, and in silico electrophysiology to examine alterations in neural circuit behavior. Their results suggest that reduction of NMDARs leads to increased excitability and seizure activity, and highlights the potential use of receptor-specific treatments in antibody-mediated seizures and epilepsy.
format	article
author	Sukhvir K. Wright Richard E. Rosch Max A. Wilson Manoj A. Upadhya Divya R. Dhangar Charlie Clarke-Bland Tamara T. Wahid Sumanta Barman Norbert Goebels Jakob Kreye Harald Prüss Leslie Jacobson Danielle S. Bassett Angela Vincent Stuart D. Greenhill Gavin L. Woodhall
author_facet	Sukhvir K. Wright Richard E. Rosch Max A. Wilson Manoj A. Upadhya Divya R. Dhangar Charlie Clarke-Bland Tamara T. Wahid Sumanta Barman Norbert Goebels Jakob Kreye Harald Prüss Leslie Jacobson Danielle S. Bassett Angela Vincent Stuart D. Greenhill Gavin L. Woodhall
author_sort	Sukhvir K. Wright
title	Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
title_short	Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
title_full	Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
title_fullStr	Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
title_full_unstemmed	Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis
title_sort	multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of nmdar antibody-mediated encephalitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/044abfeed3bf450a87ab1e4b273bc087
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Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated encephalitis

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