Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

Abstract Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a...

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Autores principales:	Samantha Sze-Yee Lee, Darren John Beales, Fred K. Chen, Seyhan Yazar, David Alonso-Caneiro, David A. Mackey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/044b5130993e4db2ae4b6b2c4457ae75
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spelling	oai:doaj.org-article:044b5130993e4db2ae4b6b2c4457ae752021-12-02T16:31:03ZAssociations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults10.1038/s41598-021-85626-32045-2322https://doaj.org/article/044b5130993e4db2ae4b6b2c4457ae752021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85626-3https://doaj.org/toc/2045-2322Abstract Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18–22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sample), increasing (11%), or consistently high (11%). 340 and 1035 participants were included in the choroidal and retinal thickness analyses, respectively. Compared to those in the “Low” trajectory group, participants in the “Increasing” and “High” groups had 14–21 μm thinner choroids at most macular regions. Every additional pack-year smoked was linked with a 0.06–0.10 μm thinner retina at the inner and outer macular rings, suggesting a dose-dependent relationship between smoking and thinner retinas. These associations may suggest that an increased risk of future visual impairment or eye disease associated with these risk factors may be present since young adulthood.Samantha Sze-Yee LeeDarren John BealesFred K. ChenSeyhan YazarDavid Alonso-CaneiroDavid A. MackeyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samantha Sze-Yee Lee Darren John Beales Fred K. Chen Seyhan Yazar David Alonso-Caneiro David A. Mackey Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
description	Abstract Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein (CRP) level trajectory and pack-years smoked. Participants from the Raine study, a longitudinal cohort study, had serum CRP levels analysed at the 14-, 17-, and 20-year follow-ups. Group-based trajectory modelling was used to classify participants according to their 7-year CRP levels. At the 20-year follow-up (at 18–22 years old), participants completed questionnaires on their smoking history, and underwent optical coherence tomography imaging to obtain their choroidal and retinal thicknesses at the macula. Three CRP trajectories were identified: consistently low CRP levels (78% of sample), increasing (11%), or consistently high (11%). 340 and 1035 participants were included in the choroidal and retinal thickness analyses, respectively. Compared to those in the “Low” trajectory group, participants in the “Increasing” and “High” groups had 14–21 μm thinner choroids at most macular regions. Every additional pack-year smoked was linked with a 0.06–0.10 μm thinner retina at the inner and outer macular rings, suggesting a dose-dependent relationship between smoking and thinner retinas. These associations may suggest that an increased risk of future visual impairment or eye disease associated with these risk factors may be present since young adulthood.
format	article
author	Samantha Sze-Yee Lee Darren John Beales Fred K. Chen Seyhan Yazar David Alonso-Caneiro David A. Mackey
author_facet	Samantha Sze-Yee Lee Darren John Beales Fred K. Chen Seyhan Yazar David Alonso-Caneiro David A. Mackey
author_sort	Samantha Sze-Yee Lee
title	Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
title_short	Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
title_full	Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
title_fullStr	Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
title_full_unstemmed	Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
title_sort	associations between seven-year c-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/044b5130993e4db2ae4b6b2c4457ae75
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Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

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