Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.

<h4>Summary</h4>The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA inde...

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Autores principales:	Maria Luisa Mansego, Fernando Martínez, Maria Teresa Martínez-Larrad, Carina Zabena, Gemma Rojo, Sonsoles Morcillo, Federico Soriguer, Juan Carlos Martín-Escudero, Manuel Serrano-Ríos, Josep Redon, Felipe Javier Chaves
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/044bb250d92e415bb845a5dce73f528c
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spelling	oai:doaj.org-article:044bb250d92e415bb845a5dce73f528c2021-11-18T07:26:15ZCommon variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.1932-620310.1371/journal.pone.0031853https://doaj.org/article/044bb250d92e415bb845a5dce73f528c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22396741/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Summary</h4>The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.<h4>Methods</h4>1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.<h4>Results</h4>One polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population.<h4>Conclusions</h4>The study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians.Maria Luisa MansegoFernando MartínezMaria Teresa Martínez-LarradCarina ZabenaGemma RojoSonsoles MorcilloFederico SoriguerJuan Carlos Martín-EscuderoManuel Serrano-RíosJosep RedonFelipe Javier ChavesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e31853 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Luisa Mansego Fernando Martínez Maria Teresa Martínez-Larrad Carina Zabena Gemma Rojo Sonsoles Morcillo Federico Soriguer Juan Carlos Martín-Escudero Manuel Serrano-Ríos Josep Redon Felipe Javier Chaves Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
description	<h4>Summary</h4>The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.<h4>Methods</h4>1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.<h4>Results</h4>One polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population.<h4>Conclusions</h4>The study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians.
format	article
author	Maria Luisa Mansego Fernando Martínez Maria Teresa Martínez-Larrad Carina Zabena Gemma Rojo Sonsoles Morcillo Federico Soriguer Juan Carlos Martín-Escudero Manuel Serrano-Ríos Josep Redon Felipe Javier Chaves
author_facet	Maria Luisa Mansego Fernando Martínez Maria Teresa Martínez-Larrad Carina Zabena Gemma Rojo Sonsoles Morcillo Federico Soriguer Juan Carlos Martín-Escudero Manuel Serrano-Ríos Josep Redon Felipe Javier Chaves
author_sort	Maria Luisa Mansego
title	Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
title_short	Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
title_full	Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
title_fullStr	Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
title_full_unstemmed	Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
title_sort	common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in spanish population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/044bb250d92e415bb845a5dce73f528c
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Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.

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