Structure aided design of a Neu5Gc specific lectin

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Structure aided design of a Neu5Gc specific lectin

Abstract Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells. Elevate...

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Auteurs principaux:	Christopher J. Day, Adrienne W. Paton, Melanie A. Higgins, Lucy K. Shewell, Freda E.-C. Jen, Benjamin L. Schulz, Brock P. Herdman, James C. Paton, Michael P. Jennings
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/044bf5c3974f4b87808e48ec6742c49f
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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