Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

Oral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providi...

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Autores principales:	Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oral mucositis inflammation polyunsaturated fatty acids omega-3 fatty acids omega-6 fatty acids cancer Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/044ccab3dbd24e4a93401771a7dbf84e
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spelling	oai:doaj.org-article:044ccab3dbd24e4a93401771a7dbf84e2021-11-25T16:48:39ZOral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review10.3390/biomedicines91115312227-9059https://doaj.org/article/044ccab3dbd24e4a93401771a7dbf84e2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1531https://doaj.org/toc/2227-9059Oral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providing sufficient prevention and treatment; new approaches to injury management are needed. Studies on the benefit of omega-3 free fatty acids (FFA) in human health have increased significantly in recent years. FFA properties have been studied extensively, including their potential therapeutic use in inflammatory conditions. However, omega-3 FFA’s use as a supplementary treatment for OM has not been clinically tested. Preliminary evidence suggests that utilising FFA to manage OM could be a useful strategy for lesion management, assisting with healthy oral mucosa recovery. This review will describe the incidence, risk factors, biology of OM and the current treatment strategies, leading to a discussion of the utility of omega-3 FFA as a novel therapeutic agent for OM.Roberta Cardim LessaFabio de Abreu AlvesErika FortunatiJun LuMDPI AGarticleoral mucositisinflammationpolyunsaturated fatty acidsomega-3 fatty acidsomega-6 fatty acidscancerBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1531, p 1531 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral mucositis inflammation polyunsaturated fatty acids omega-3 fatty acids omega-6 fatty acids cancer Biology (General) QH301-705.5
spellingShingle	oral mucositis inflammation polyunsaturated fatty acids omega-3 fatty acids omega-6 fatty acids cancer Biology (General) QH301-705.5 Roberta Cardim Lessa Fabio de Abreu Alves Erika Fortunati Jun Lu Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
description	Oral mucositis (OM) is a painful condition caused by chemotherapeutic or radiotherapeutic cancer treatments, occurring in patients with different tumour characteristics and locations. OM greatly impacts a patient’s quality of life and cancer recovery. Current OM management strategies are not providing sufficient prevention and treatment; new approaches to injury management are needed. Studies on the benefit of omega-3 free fatty acids (FFA) in human health have increased significantly in recent years. FFA properties have been studied extensively, including their potential therapeutic use in inflammatory conditions. However, omega-3 FFA’s use as a supplementary treatment for OM has not been clinically tested. Preliminary evidence suggests that utilising FFA to manage OM could be a useful strategy for lesion management, assisting with healthy oral mucosa recovery. This review will describe the incidence, risk factors, biology of OM and the current treatment strategies, leading to a discussion of the utility of omega-3 FFA as a novel therapeutic agent for OM.
format	article
author	Roberta Cardim Lessa Fabio de Abreu Alves Erika Fortunati Jun Lu
author_facet	Roberta Cardim Lessa Fabio de Abreu Alves Erika Fortunati Jun Lu
author_sort	Roberta Cardim Lessa
title	Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
title_short	Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
title_full	Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
title_fullStr	Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
title_full_unstemmed	Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review
title_sort	oral mucositis in cancer and potential use of omega-3 free fatty acids in its management: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/044ccab3dbd24e4a93401771a7dbf84e
work_keys_str_mv	AT robertacardimlessa oralmucositisincancerandpotentialuseofomega3freefattyacidsinitsmanagementareview AT fabiodeabreualves oralmucositisincancerandpotentialuseofomega3freefattyacidsinitsmanagementareview AT erikafortunati oralmucositisincancerandpotentialuseofomega3freefattyacidsinitsmanagementareview AT junlu oralmucositisincancerandpotentialuseofomega3freefattyacidsinitsmanagementareview
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Oral Mucositis in Cancer and Potential Use of Omega-3 Free Fatty Acids in Its Management: A Review

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