Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review

Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review

Jingjing You,1,2 Chris Hodge,1,3– 5 Monira Hoque,4 Constantinos Petsoglou,1,4 Gerard Sutton1,3,4 1Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; 2School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 3Vision Eye Institute,...

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Autores principales: You J, Hodge C, Hoque M, Petsoglou C, Sutton G
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
platelet rich plasma
human platelet lysate
dry eye syndrome
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/044d86d16e44472aa2079de0991d1869
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spelling oai:doaj.org-article:044d86d16e44472aa2079de0991d18692021-12-02T12:16:01ZHuman Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review1177-5483https://doaj.org/article/044d86d16e44472aa2079de0991d18692020-10-01T00:00:00Zhttps://www.dovepress.com/human-platelets-and-derived-products-in-treating-ocular-surface-diseas-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jingjing You,1,2 Chris Hodge,1,3– 5 Monira Hoque,4 Constantinos Petsoglou,1,4 Gerard Sutton1,3,4 1Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; 2School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 3Vision Eye Institute, Chatswood, Sydney, NSW, Australia; 4NSW Tissue Bank, Sydney, NSW, Australia; 5Graduate School of Health, University of Technology Sydney, Sydney, NSW, AustraliaCorrespondence: Jingjing YouSave Sight Institute, Sydney Medical School, University of Sydney, 8 Macquarie Street, Sydney 2001, AustraliaEmail jing.you@sydney.edu.auAbstract: Human platelet products have emerged as an alternative treatment for a range of ocular surface diseases such as dry eye and corneal ulceration. With significant therapeutic potential and increasing popularity, this study aimed to conduct a systematic review to detail the various production methods involved in generating platelet-derived products, compare and analyze clinical findings across available studies, and disseminate the relative advantages, limitations, and challenges of using platelet products to treat ocular surface disease. Thirty-eight clinical studies were identified, excluding studies conducted in animals and non-English language. Studies reported clinical outcomes, which included ocular surface disease index, best-corrected visual acuity, and corneal fluorescein staining. Most clinical studies reported improved patient signs and symptoms with an increasing variety of human platelet products including platelet rich plasma eye drops, human platelet lysate and platelet gels. However, due to variations in production methods, and study designs as well as confusing terminology, it was suggested that characterization of platelet products is needed for proper evaluation across studies.Keywords: platelet rich plasma, human platelet lysate, dry eye syndromeYou JHodge CHoque MPetsoglou CSutton GDove Medical Pressarticleplatelet rich plasmahuman platelet lysatedry eye syndromeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3195-3210 (2020)
institution DOAJ
collection DOAJ
language EN
topic platelet rich plasma
human platelet lysate
dry eye syndrome
Ophthalmology
RE1-994
spellingShingle platelet rich plasma
human platelet lysate
dry eye syndrome
Ophthalmology
RE1-994
You J
Hodge C
Hoque M
Petsoglou C
Sutton G
Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
description Jingjing You,1,2 Chris Hodge,1,3– 5 Monira Hoque,4 Constantinos Petsoglou,1,4 Gerard Sutton1,3,4 1Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; 2School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 3Vision Eye Institute, Chatswood, Sydney, NSW, Australia; 4NSW Tissue Bank, Sydney, NSW, Australia; 5Graduate School of Health, University of Technology Sydney, Sydney, NSW, AustraliaCorrespondence: Jingjing YouSave Sight Institute, Sydney Medical School, University of Sydney, 8 Macquarie Street, Sydney 2001, AustraliaEmail jing.you@sydney.edu.auAbstract: Human platelet products have emerged as an alternative treatment for a range of ocular surface diseases such as dry eye and corneal ulceration. With significant therapeutic potential and increasing popularity, this study aimed to conduct a systematic review to detail the various production methods involved in generating platelet-derived products, compare and analyze clinical findings across available studies, and disseminate the relative advantages, limitations, and challenges of using platelet products to treat ocular surface disease. Thirty-eight clinical studies were identified, excluding studies conducted in animals and non-English language. Studies reported clinical outcomes, which included ocular surface disease index, best-corrected visual acuity, and corneal fluorescein staining. Most clinical studies reported improved patient signs and symptoms with an increasing variety of human platelet products including platelet rich plasma eye drops, human platelet lysate and platelet gels. However, due to variations in production methods, and study designs as well as confusing terminology, it was suggested that characterization of platelet products is needed for proper evaluation across studies.Keywords: platelet rich plasma, human platelet lysate, dry eye syndrome
format article
author You J
Hodge C
Hoque M
Petsoglou C
Sutton G
author_facet You J
Hodge C
Hoque M
Petsoglou C
Sutton G
author_sort You J
title Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
title_short Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
title_full Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
title_fullStr Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
title_full_unstemmed Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review
title_sort human platelets and derived products in treating ocular surface diseases – a systematic review
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/044d86d16e44472aa2079de0991d1869
work_keys_str_mv AT youj humanplateletsandderivedproductsintreatingocularsurfacediseasesndashasystematicreview
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AT hoquem humanplateletsandderivedproductsintreatingocularsurfacediseasesndashasystematicreview
AT petsoglouc humanplateletsandderivedproductsintreatingocularsurfacediseasesndashasystematicreview
AT suttong humanplateletsandderivedproductsintreatingocularsurfacediseasesndashasystematicreview
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