Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids

Abstract Reduced taste sensitivity to 6-n-propylthiouracil (PROP), a genetic trait regarded as a general index for oral chemosensory perception, has been associated with a calorie-rich food preference and lower circulating endocannabinoid levels in participants with normal weight (NW), which suggest...

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Autores principales:	Gianfranca Carta, Melania Melis, Stefano Pintus, Paolo Pintus, Carla A. Piras, Laura Muredda, Daniela Demurtas, Vincenzo Di Marzo, Sebastiano Banni, Iole Tomassini Barbarossa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/044e5aee3e6c42f39187e7b686e46d24
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spelling	oai:doaj.org-article:044e5aee3e6c42f39187e7b686e46d242021-12-02T11:52:59ZParticipants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids10.1038/s41598-017-01562-12045-2322https://doaj.org/article/044e5aee3e6c42f39187e7b686e46d242017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01562-1https://doaj.org/toc/2045-2322Abstract Reduced taste sensitivity to 6-n-propylthiouracil (PROP), a genetic trait regarded as a general index for oral chemosensory perception, has been associated with a calorie-rich food preference and lower circulating endocannabinoid levels in participants with normal weight (NW), which suggests an adaptive mechanism to maintain a lean phenotype. In this study, we assessed whether participants with obesity (OB) show different patterns of plasma endocannabinoids and lipid metabolism biomarkers from those of NW, with further categorization based on their PROP sensitivity. NW and OB were classified by their PROP taster status as non-tasters (NT), medium-tasters (MT) and supertasters (ST). The blood samples were analysed for plasma endocannabinoids, nonesterified fatty acids (NEFA) and retinol, which have been associated to metabolic syndrome. In OB, we found a higher BMI and lower circulating endocannabinoids in ST vs. OB NT. However, OB ST showed lower circulating NEFA and retinol levels, which suggested a more favourable lipid metabolism and body fat distribution than those of OB NT. We confirmed lower plasma endocannabinoid levels in NW NT than in NW ST. These data suggest that PROP taste sensitivity determines metabolic changes and ultimately body mass composition differently in OB and NW.Gianfranca CartaMelania MelisStefano PintusPaolo PintusCarla A. PirasLaura MureddaDaniela DemurtasVincenzo Di MarzoSebastiano BanniIole Tomassini BarbarossaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gianfranca Carta Melania Melis Stefano Pintus Paolo Pintus Carla A. Piras Laura Muredda Daniela Demurtas Vincenzo Di Marzo Sebastiano Banni Iole Tomassini Barbarossa Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
description	Abstract Reduced taste sensitivity to 6-n-propylthiouracil (PROP), a genetic trait regarded as a general index for oral chemosensory perception, has been associated with a calorie-rich food preference and lower circulating endocannabinoid levels in participants with normal weight (NW), which suggests an adaptive mechanism to maintain a lean phenotype. In this study, we assessed whether participants with obesity (OB) show different patterns of plasma endocannabinoids and lipid metabolism biomarkers from those of NW, with further categorization based on their PROP sensitivity. NW and OB were classified by their PROP taster status as non-tasters (NT), medium-tasters (MT) and supertasters (ST). The blood samples were analysed for plasma endocannabinoids, nonesterified fatty acids (NEFA) and retinol, which have been associated to metabolic syndrome. In OB, we found a higher BMI and lower circulating endocannabinoids in ST vs. OB NT. However, OB ST showed lower circulating NEFA and retinol levels, which suggested a more favourable lipid metabolism and body fat distribution than those of OB NT. We confirmed lower plasma endocannabinoid levels in NW NT than in NW ST. These data suggest that PROP taste sensitivity determines metabolic changes and ultimately body mass composition differently in OB and NW.
format	article
author	Gianfranca Carta Melania Melis Stefano Pintus Paolo Pintus Carla A. Piras Laura Muredda Daniela Demurtas Vincenzo Di Marzo Sebastiano Banni Iole Tomassini Barbarossa
author_facet	Gianfranca Carta Melania Melis Stefano Pintus Paolo Pintus Carla A. Piras Laura Muredda Daniela Demurtas Vincenzo Di Marzo Sebastiano Banni Iole Tomassini Barbarossa
author_sort	Gianfranca Carta
title	Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
title_short	Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
title_full	Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
title_fullStr	Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
title_full_unstemmed	Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids
title_sort	participants with normal weight or with obesity show different relationships of 6-n-propylthiouracil (prop) taster status with bmi and plasma endocannabinoids
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/044e5aee3e6c42f39187e7b686e46d24
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Participants with Normal Weight or with Obesity Show Different Relationships of 6-n-Propylthiouracil (PROP) Taster Status with BMI and Plasma Endocannabinoids

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