Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria

Abstract In 2017, the WHO classification of tumours of the endocrine organs established the criteria for a NIFTP diagnosis. The present paper considers some aspects that are still debated or unresolved: the real incidence and clinical meaning of multifocal/multinodular lesions, the biological behavi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Valentina Canini, Davide Leni, Angela Ida Pincelli, Marcella Scardilli, Mattia Garancini, Chiara Villa, Camillo Di Bella, Giulia Capitoli, Riccardo Cimini, Biagio Eugenio Leone, Fabio Pagni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04500db918d74c9991719d8925934281
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:04500db918d74c9991719d8925934281
record_format	dspace
spelling	oai:doaj.org-article:04500db918d74c9991719d89259342812021-12-02T15:09:16ZClinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria10.1038/s41598-019-49851-12045-2322https://doaj.org/article/04500db918d74c9991719d89259342812019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49851-1https://doaj.org/toc/2045-2322Abstract In 2017, the WHO classification of tumours of the endocrine organs established the criteria for a NIFTP diagnosis. The present paper considers some aspects that are still debated or unresolved: the real incidence and clinical meaning of multifocal/multinodular lesions, the biological behaviour of micro-NIFTP, the sprinkling phenomenon and the corresponding modifications to the FNA reporting systems based on changes to the ROM. Moreover, the paper suggests possible scenarios for the clinical-pathological management of this entity. From the initial 1470 cases, a group of 68 NIFTPs was recruited in a 9 year-long period. The average age at diagnosis was 55 years. The average diameter of the lesion was 1.7 cm (0.1 cm–10 cm). In 41 cases (60.1%), the lesion was inserted in the context of a multinodular background. In 12 cases, the diagnosis was incidental and the pre- operative FNA was performed on a different target. In 10 out of 68 cases, there was a multifocal NIFTP; in 14.7% of patients, PTC-like nuclear features showed sprinkling phenomenon. The cytological revision allocated 21 cases (49%) to the SIAPEC TIR3 indeterminate class and a nuclear score 2 or 3 were identified in 25 smears. Multifocality is part of the spectrum of NIFTPs, that can arise in a multinodular background with variable sizes from microscopic lesions to very large ones. Cytopathological criteria such as an evaluation of the nuclear score may help the pathologists in promoting a NIFTP diagnosis in the preoperative setting.Valentina CaniniDavide LeniAngela Ida PincelliMarcella ScardilliMattia GaranciniChiara VillaCamillo Di BellaGiulia CapitoliRiccardo CiminiBiagio Eugenio LeoneFabio PagniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valentina Canini Davide Leni Angela Ida Pincelli Marcella Scardilli Mattia Garancini Chiara Villa Camillo Di Bella Giulia Capitoli Riccardo Cimini Biagio Eugenio Leone Fabio Pagni Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
description	Abstract In 2017, the WHO classification of tumours of the endocrine organs established the criteria for a NIFTP diagnosis. The present paper considers some aspects that are still debated or unresolved: the real incidence and clinical meaning of multifocal/multinodular lesions, the biological behaviour of micro-NIFTP, the sprinkling phenomenon and the corresponding modifications to the FNA reporting systems based on changes to the ROM. Moreover, the paper suggests possible scenarios for the clinical-pathological management of this entity. From the initial 1470 cases, a group of 68 NIFTPs was recruited in a 9 year-long period. The average age at diagnosis was 55 years. The average diameter of the lesion was 1.7 cm (0.1 cm–10 cm). In 41 cases (60.1%), the lesion was inserted in the context of a multinodular background. In 12 cases, the diagnosis was incidental and the pre- operative FNA was performed on a different target. In 10 out of 68 cases, there was a multifocal NIFTP; in 14.7% of patients, PTC-like nuclear features showed sprinkling phenomenon. The cytological revision allocated 21 cases (49%) to the SIAPEC TIR3 indeterminate class and a nuclear score 2 or 3 were identified in 25 smears. Multifocality is part of the spectrum of NIFTPs, that can arise in a multinodular background with variable sizes from microscopic lesions to very large ones. Cytopathological criteria such as an evaluation of the nuclear score may help the pathologists in promoting a NIFTP diagnosis in the preoperative setting.
format	article
author	Valentina Canini Davide Leni Angela Ida Pincelli Marcella Scardilli Mattia Garancini Chiara Villa Camillo Di Bella Giulia Capitoli Riccardo Cimini Biagio Eugenio Leone Fabio Pagni
author_facet	Valentina Canini Davide Leni Angela Ida Pincelli Marcella Scardilli Mattia Garancini Chiara Villa Camillo Di Bella Giulia Capitoli Riccardo Cimini Biagio Eugenio Leone Fabio Pagni
author_sort	Valentina Canini
title	Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
title_short	Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
title_full	Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
title_fullStr	Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
title_full_unstemmed	Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria
title_sort	clinical-pathological issues in thyroid pathology: study on the routine application of niftp diagnostic criteria
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/04500db918d74c9991719d8925934281
work_keys_str_mv	AT valentinacanini clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT davideleni clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT angelaidapincelli clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT marcellascardilli clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT mattiagarancini clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT chiaravilla clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT camillodibella clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT giuliacapitoli clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT riccardocimini clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT biagioeugenioleone clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria AT fabiopagni clinicalpathologicalissuesinthyroidpathologystudyontheroutineapplicationofniftpdiagnosticcriteria
_version_	1718387855344009216

Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria

Ejemplares similares