Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study
Haixia Wang, Chenxiao Bai, Mo Yi, Yuanmin Jia, Yizhang Li, Di Jiang, Ou Chen School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People’s Republic of ChinaCorrespondence: Ou ChenSchool of Nursing, Cheeloo College of Medicine, Shandong University, Ji...
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2020
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oai:doaj.org-article:0452501e5fc14ddeb970c7cf172d86ea2021-12-02T12:07:47ZMetabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study1178-7007https://doaj.org/article/0452501e5fc14ddeb970c7cf172d86ea2020-09-01T00:00:00Zhttps://www.dovepress.com/metabolic-syndrome-and-incident-asthma-in-chinese-adults-an-open-cohor-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Haixia Wang, Chenxiao Bai, Mo Yi, Yuanmin Jia, Yizhang Li, Di Jiang, Ou Chen School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People’s Republic of ChinaCorrespondence: Ou ChenSchool of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People’s Republic of ChinaTel +8615990991181Email chenou@sdu.edu.cnBackground: Although metabolic syndrome is awell-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial.Objective: The aim of this study was to explore the associations of metabolic syndrome and its components with incident asthma in Chinese adults.Methods: We conducted an open cohort study of participants who were asthma-free at baseline (n=42,304) in the Shandong multi-center health check-up longitudinal study from 2004 to 2015. Participants aged ≥ 20 years and had regular physical examination (once ayear) more than three times during follow-up.Results: Ninety subjects (38 women and 52 men) developed incident asthma over 12 years of follow-up. Our study suggested that metabolic syndrome itself was not significantly associated with incident asthma in either women or men (P> 0.050). Interestingly, we found that overweight and/or obesity was arisk factor for incident asthma among women but not men in the Cox proportional hazards model after adjusting covariates (adjusted incidence rate ratio (IRR)= 2.940, 95% confidence interval (CI): 1.467– 5.894, P=0.002). The result was consistent with the Poisson regression model (hazard ratio (HR)= 2.241, 95% CI: 1.135– 4.988, P=0.026). After stratifying according to overweight and/or obesity, we found that female subjects with overweight and obesity were associated with the occurrence of incident asthma (P< 0.050). However, we did not find this result among men. Conclusion: Metabolic syndrome was not significantly associated with incident asthma in both women and men; however, overweight and/or obesity was shown to be asignificant risk factor for incident asthma but only in women, not in men.Keywords: overweight and/or obesity, metabolic syndrome, risk factor, incident asthmaWang HBai CYi MJia YLi YJiang DChen ODove Medical Pressarticleoverweight and/or obesitymetabolic syndromerisk factorincident asthmaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3411-3420 (2020) |
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overweight and/or obesity metabolic syndrome risk factor incident asthma Specialties of internal medicine RC581-951 |
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overweight and/or obesity metabolic syndrome risk factor incident asthma Specialties of internal medicine RC581-951 Wang H Bai C Yi M Jia Y Li Y Jiang D Chen O Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| description |
Haixia Wang, Chenxiao Bai, Mo Yi, Yuanmin Jia, Yizhang Li, Di Jiang, Ou Chen School of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People’s Republic of ChinaCorrespondence: Ou ChenSchool of Nursing, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, People’s Republic of ChinaTel +8615990991181Email chenou@sdu.edu.cnBackground: Although metabolic syndrome is awell-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial.Objective: The aim of this study was to explore the associations of metabolic syndrome and its components with incident asthma in Chinese adults.Methods: We conducted an open cohort study of participants who were asthma-free at baseline (n=42,304) in the Shandong multi-center health check-up longitudinal study from 2004 to 2015. Participants aged ≥ 20 years and had regular physical examination (once ayear) more than three times during follow-up.Results: Ninety subjects (38 women and 52 men) developed incident asthma over 12 years of follow-up. Our study suggested that metabolic syndrome itself was not significantly associated with incident asthma in either women or men (P> 0.050). Interestingly, we found that overweight and/or obesity was arisk factor for incident asthma among women but not men in the Cox proportional hazards model after adjusting covariates (adjusted incidence rate ratio (IRR)= 2.940, 95% confidence interval (CI): 1.467– 5.894, P=0.002). The result was consistent with the Poisson regression model (hazard ratio (HR)= 2.241, 95% CI: 1.135– 4.988, P=0.026). After stratifying according to overweight and/or obesity, we found that female subjects with overweight and obesity were associated with the occurrence of incident asthma (P< 0.050). However, we did not find this result among men. Conclusion: Metabolic syndrome was not significantly associated with incident asthma in both women and men; however, overweight and/or obesity was shown to be asignificant risk factor for incident asthma but only in women, not in men.Keywords: overweight and/or obesity, metabolic syndrome, risk factor, incident asthma |
| format |
article |
| author |
Wang H Bai C Yi M Jia Y Li Y Jiang D Chen O |
| author_facet |
Wang H Bai C Yi M Jia Y Li Y Jiang D Chen O |
| author_sort |
Wang H |
| title |
Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| title_short |
Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| title_full |
Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| title_fullStr |
Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| title_full_unstemmed |
Metabolic Syndrome and Incident Asthma in Chinese Adults: An Open Cohort Study |
| title_sort |
metabolic syndrome and incident asthma in chinese adults: an open cohort study |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/0452501e5fc14ddeb970c7cf172d86ea |
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