Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques

For combining optical and ultrasonic imaging methodologies, photoacoustic imaging (PAI) is the most important and successful hybrid technique, which has greatly contributed to biomedical research and applications. Its theoretical background is based on the photoacoustic effect, whereby a modulated o...

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Autores principales:	Zuomin Zhao, Teemu Myllylä
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	photoacoustic imaging modality optical ultrasonic brain Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/04549af75222466ea7f403cee788f5c5
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spelling	oai:doaj.org-article:04549af75222466ea7f403cee788f5c52021-11-11T14:57:42ZRecent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques10.3390/app112198042076-3417https://doaj.org/article/04549af75222466ea7f403cee788f5c52021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9804https://doaj.org/toc/2076-3417For combining optical and ultrasonic imaging methodologies, photoacoustic imaging (PAI) is the most important and successful hybrid technique, which has greatly contributed to biomedical research and applications. Its theoretical background is based on the photoacoustic effect, whereby a modulated or pulsed light is emitted into tissue, which selectively absorbs the optical energy of the light at optical wavelengths. This energy produces a fast thermal expansion in the illuminated tissue, generating pressure waves (or photoacoustic waves) that can be detected by ultrasonic transducers. Research has shown that optical absorption spectroscopy offers high optical sensitivity and contrast for ingredient determination, for example, while ultrasound has demonstrated good spatial resolution in biomedical imaging. Photoacoustic imaging combines these advantages, i.e., high contrast through optical absorption and high spatial resolution due to the low scattering of ultrasound in tissue. In this review, we focus on advances made in PAI in the last five years and present categories and key devices used in PAI techniques. In particular, we highlight the continuously increasing imaging depth achieved by PAI, particularly when using exogenous reagents. Finally, we discuss the potential of combining PAI with other imaging techniques.Zuomin ZhaoTeemu MyllyläMDPI AGarticlephotoacousticimaging modalityopticalultrasonicbrainTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9804, p 9804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	photoacoustic imaging modality optical ultrasonic brain Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	photoacoustic imaging modality optical ultrasonic brain Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Zuomin Zhao Teemu Myllylä Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
description	For combining optical and ultrasonic imaging methodologies, photoacoustic imaging (PAI) is the most important and successful hybrid technique, which has greatly contributed to biomedical research and applications. Its theoretical background is based on the photoacoustic effect, whereby a modulated or pulsed light is emitted into tissue, which selectively absorbs the optical energy of the light at optical wavelengths. This energy produces a fast thermal expansion in the illuminated tissue, generating pressure waves (or photoacoustic waves) that can be detected by ultrasonic transducers. Research has shown that optical absorption spectroscopy offers high optical sensitivity and contrast for ingredient determination, for example, while ultrasound has demonstrated good spatial resolution in biomedical imaging. Photoacoustic imaging combines these advantages, i.e., high contrast through optical absorption and high spatial resolution due to the low scattering of ultrasound in tissue. In this review, we focus on advances made in PAI in the last five years and present categories and key devices used in PAI techniques. In particular, we highlight the continuously increasing imaging depth achieved by PAI, particularly when using exogenous reagents. Finally, we discuss the potential of combining PAI with other imaging techniques.
format	article
author	Zuomin Zhao Teemu Myllylä
author_facet	Zuomin Zhao Teemu Myllylä
author_sort	Zuomin Zhao
title	Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
title_short	Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
title_full	Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
title_fullStr	Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
title_full_unstemmed	Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques
title_sort	recent technical progression in photoacoustic imaging—towards using contrast agents and multimodal techniques
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/04549af75222466ea7f403cee788f5c5
work_keys_str_mv	AT zuominzhao recenttechnicalprogressioninphotoacousticimagingtowardsusingcontrastagentsandmultimodaltechniques AT teemumyllyla recenttechnicalprogressioninphotoacousticimagingtowardsusingcontrastagentsandmultimodaltechniques
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Recent Technical Progression in Photoacoustic Imaging—Towards Using Contrast Agents and Multimodal Techniques

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