Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes

Methodological advances have increased our understanding of chromatin structure through chromosome conformation capture techniques and high resolution imaging, but integration of these datasets is challenging. Here the authors propose GEM-FISH, a method for reconstructing the 3D models of chromosome...

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Autores principales:	Ahmed Abbas, Xuan He, Jing Niu, Bin Zhou, Guangxiang Zhu, Tszshan Ma, Jiangpeikun Song, Juntao Gao, Michael Q. Zhang, Jianyang Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/045621245b8a43758353a48a4ff3c3ac
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id	oai:doaj.org-article:045621245b8a43758353a48a4ff3c3ac
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spelling	oai:doaj.org-article:045621245b8a43758353a48a4ff3c3ac2021-12-02T14:40:17ZIntegrating Hi-C and FISH data for modeling of the 3D organization of chromosomes10.1038/s41467-019-10005-62041-1723https://doaj.org/article/045621245b8a43758353a48a4ff3c3ac2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10005-6https://doaj.org/toc/2041-1723Methodological advances have increased our understanding of chromatin structure through chromosome conformation capture techniques and high resolution imaging, but integration of these datasets is challenging. Here the authors propose GEM-FISH, a method for reconstructing the 3D models of chromosomes through systematically integrating both Hi-C and FISH data with the prior biophysical knowledge of a polymer model.Ahmed AbbasXuan HeJing NiuBin ZhouGuangxiang ZhuTszshan MaJiangpeikun SongJuntao GaoMichael Q. ZhangJianyang ZengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmed Abbas Xuan He Jing Niu Bin Zhou Guangxiang Zhu Tszshan Ma Jiangpeikun Song Juntao Gao Michael Q. Zhang Jianyang Zeng Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
description	Methodological advances have increased our understanding of chromatin structure through chromosome conformation capture techniques and high resolution imaging, but integration of these datasets is challenging. Here the authors propose GEM-FISH, a method for reconstructing the 3D models of chromosomes through systematically integrating both Hi-C and FISH data with the prior biophysical knowledge of a polymer model.
format	article
author	Ahmed Abbas Xuan He Jing Niu Bin Zhou Guangxiang Zhu Tszshan Ma Jiangpeikun Song Juntao Gao Michael Q. Zhang Jianyang Zeng
author_facet	Ahmed Abbas Xuan He Jing Niu Bin Zhou Guangxiang Zhu Tszshan Ma Jiangpeikun Song Juntao Gao Michael Q. Zhang Jianyang Zeng
author_sort	Ahmed Abbas
title	Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
title_short	Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
title_full	Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
title_fullStr	Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
title_full_unstemmed	Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes
title_sort	integrating hi-c and fish data for modeling of the 3d organization of chromosomes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/045621245b8a43758353a48a4ff3c3ac
work_keys_str_mv	AT ahmedabbas integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT xuanhe integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT jingniu integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT binzhou integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT guangxiangzhu integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT tszshanma integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT jiangpeikunsong integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT juntaogao integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT michaelqzhang integratinghicandfishdataformodelingofthe3dorganizationofchromosomes AT jianyangzeng integratinghicandfishdataformodelingofthe3dorganizationofchromosomes
_version_	1718390336352419840

Integrating Hi-C and FISH data for modeling of the 3D organization of chromosomes

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