Orbital Signaling in Graves’ Orbitopathy

Graves’ orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and underpins the majority of GO signs and symptoms. While there is strong evidence for t...

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Autores principales:	Mohd Shazli Draman, Lei Zhang, Colin Dayan, Marian Ludgate
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	thyroid eye disease adipogenesis hyaluronan TSAB TSHR IGF1R Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/0456f4bc26fe4bcebabc3b17081127c1
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id	oai:doaj.org-article:0456f4bc26fe4bcebabc3b17081127c1
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spelling	oai:doaj.org-article:0456f4bc26fe4bcebabc3b17081127c12021-11-09T05:31:22ZOrbital Signaling in Graves’ Orbitopathy1664-239210.3389/fendo.2021.739994https://doaj.org/article/0456f4bc26fe4bcebabc3b17081127c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.739994/fullhttps://doaj.org/toc/1664-2392Graves’ orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and underpins the majority of GO signs and symptoms. While there is strong evidence for the thyrotropin receptor (TSHR) being a thyroid/orbit shared autoantigen, the insulin-like growth factor 1 receptor (IGF1R) is also likely to play a key role in the disease. The pathogenesis of GO has been investigated extensively in the last decade with further understanding of some aspects of the disease. This is mainly derived by using in vitro and ex vivo analysis of the orbital tissues. Here, we have summarized the features of GO pathogenesis involving target autoantigens and their signaling pathways.Mohd Shazli DramanMohd Shazli DramanLei ZhangColin DayanMarian LudgateFrontiers Media S.A.articlethyroid eye diseaseadipogenesishyaluronanTSABTSHRIGF1RDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid eye disease adipogenesis hyaluronan TSAB TSHR IGF1R Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	thyroid eye disease adipogenesis hyaluronan TSAB TSHR IGF1R Diseases of the endocrine glands. Clinical endocrinology RC648-665 Mohd Shazli Draman Mohd Shazli Draman Lei Zhang Colin Dayan Marian Ludgate Orbital Signaling in Graves’ Orbitopathy
description	Graves’ orbitopathy (GO) is a complex and poorly understood disease in which extensive remodeling of orbital tissue is dominated by adipogenesis and hyaluronan production. The resulting proptosis is disfiguring and underpins the majority of GO signs and symptoms. While there is strong evidence for the thyrotropin receptor (TSHR) being a thyroid/orbit shared autoantigen, the insulin-like growth factor 1 receptor (IGF1R) is also likely to play a key role in the disease. The pathogenesis of GO has been investigated extensively in the last decade with further understanding of some aspects of the disease. This is mainly derived by using in vitro and ex vivo analysis of the orbital tissues. Here, we have summarized the features of GO pathogenesis involving target autoantigens and their signaling pathways.
format	article
author	Mohd Shazli Draman Mohd Shazli Draman Lei Zhang Colin Dayan Marian Ludgate
author_facet	Mohd Shazli Draman Mohd Shazli Draman Lei Zhang Colin Dayan Marian Ludgate
author_sort	Mohd Shazli Draman
title	Orbital Signaling in Graves’ Orbitopathy
title_short	Orbital Signaling in Graves’ Orbitopathy
title_full	Orbital Signaling in Graves’ Orbitopathy
title_fullStr	Orbital Signaling in Graves’ Orbitopathy
title_full_unstemmed	Orbital Signaling in Graves’ Orbitopathy
title_sort	orbital signaling in graves’ orbitopathy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0456f4bc26fe4bcebabc3b17081127c1
work_keys_str_mv	AT mohdshazlidraman orbitalsignalingingravesorbitopathy AT mohdshazlidraman orbitalsignalingingravesorbitopathy AT leizhang orbitalsignalingingravesorbitopathy AT colindayan orbitalsignalingingravesorbitopathy AT marianludgate orbitalsignalingingravesorbitopathy
_version_	1718441264129507328

Orbital Signaling in Graves’ Orbitopathy

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