Heritability and responses to high fat diet of plasma lipidomics in a twin study

Abstract Lipidomics have a great potential as clinical tool for monitoring metabolic changes in health and disease. Nevertheless hardly anything is known about the heritability of lipids. Therefore, it is necessary to clarify how and how much we can affect these progresses in individuals. In our int...

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Autores principales:	Turid Frahnow, Martin A. Osterhoff, Silke Hornemann, Michael Kruse, Michal A. Surma, Christian Klose, Kai Simons, Andreas F. H. Pfeiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0457bd64ab80427fad165d8dfe28746c
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spelling	oai:doaj.org-article:0457bd64ab80427fad165d8dfe28746c2021-12-02T16:06:15ZHeritability and responses to high fat diet of plasma lipidomics in a twin study10.1038/s41598-017-03965-62045-2322https://doaj.org/article/0457bd64ab80427fad165d8dfe28746c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03965-6https://doaj.org/toc/2045-2322Abstract Lipidomics have a great potential as clinical tool for monitoring metabolic changes in health and disease. Nevertheless hardly anything is known about the heritability of lipids. Therefore, it is necessary to clarify how and how much we can affect these progresses in individuals. In our interventional twin study (46 healthy, non-obese twin pairs) we investigated the lipid profile in plasma samples after switching from a low fat diet to an isocaloric high fat diet (HFD) to characterize the metabolic adaptation. Additionally we used the ACE model for Additive genetics, Common and unique Environment as well as linear mixed modelling to analyse the heritability of lipids. The heritability of lipids varied between 0–62% and applied to lipid species rather than to lipid classes. Phospholipids showed the highest inheritance. In addition, sex, body mass index (BMI) and age were important modifiers. The lipid profile changed already after one week of HFD and diverged further after 5 weeks of additional HFD. Basal concentrations of specific lipids within phospholipids are strongly inherited and are likely to be associated with heritable disease risks. BMI, sex and age were major modifiers. Nutrition strongly alters specific lipid classes, and has to be controlled in clinical association studies.Turid FrahnowMartin A. OsterhoffSilke HornemannMichael KruseMichal A. SurmaChristian KloseKai SimonsAndreas F. H. PfeifferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Turid Frahnow Martin A. Osterhoff Silke Hornemann Michael Kruse Michal A. Surma Christian Klose Kai Simons Andreas F. H. Pfeiffer Heritability and responses to high fat diet of plasma lipidomics in a twin study
description	Abstract Lipidomics have a great potential as clinical tool for monitoring metabolic changes in health and disease. Nevertheless hardly anything is known about the heritability of lipids. Therefore, it is necessary to clarify how and how much we can affect these progresses in individuals. In our interventional twin study (46 healthy, non-obese twin pairs) we investigated the lipid profile in plasma samples after switching from a low fat diet to an isocaloric high fat diet (HFD) to characterize the metabolic adaptation. Additionally we used the ACE model for Additive genetics, Common and unique Environment as well as linear mixed modelling to analyse the heritability of lipids. The heritability of lipids varied between 0–62% and applied to lipid species rather than to lipid classes. Phospholipids showed the highest inheritance. In addition, sex, body mass index (BMI) and age were important modifiers. The lipid profile changed already after one week of HFD and diverged further after 5 weeks of additional HFD. Basal concentrations of specific lipids within phospholipids are strongly inherited and are likely to be associated with heritable disease risks. BMI, sex and age were major modifiers. Nutrition strongly alters specific lipid classes, and has to be controlled in clinical association studies.
format	article
author	Turid Frahnow Martin A. Osterhoff Silke Hornemann Michael Kruse Michal A. Surma Christian Klose Kai Simons Andreas F. H. Pfeiffer
author_facet	Turid Frahnow Martin A. Osterhoff Silke Hornemann Michael Kruse Michal A. Surma Christian Klose Kai Simons Andreas F. H. Pfeiffer
author_sort	Turid Frahnow
title	Heritability and responses to high fat diet of plasma lipidomics in a twin study
title_short	Heritability and responses to high fat diet of plasma lipidomics in a twin study
title_full	Heritability and responses to high fat diet of plasma lipidomics in a twin study
title_fullStr	Heritability and responses to high fat diet of plasma lipidomics in a twin study
title_full_unstemmed	Heritability and responses to high fat diet of plasma lipidomics in a twin study
title_sort	heritability and responses to high fat diet of plasma lipidomics in a twin study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0457bd64ab80427fad165d8dfe28746c
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Heritability and responses to high fat diet of plasma lipidomics in a twin study

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