Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.

Rhinoviruses (RV) are a major cause of Severe Acute Respiratory Infection (SARI) in children, with high genotypic diversity in different regions. However, RV type diversity remains unknown in several regions of the world. In this study, the genetic variability of the frequently circulating RV types...

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Autores principales:	Sondes Haddad-Boubaker, Cherif Ben Hamda, Kais Ghedira, Khaoula Mefteh, Aida Bouafsoun, Ilhem Boutiba-Ben Boubaker, Amin Slim, Khaled Menif, Henda Triki, Mohamed Ali Ben Hadj Kacem, Hanen Smaoui
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/04583985d59245249057b32756a607a4
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spelling	oai:doaj.org-article:04583985d59245249057b32756a607a42021-12-02T20:16:18ZPhylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.1932-620310.1371/journal.pone.0259859https://doaj.org/article/04583985d59245249057b32756a607a42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259859https://doaj.org/toc/1932-6203Rhinoviruses (RV) are a major cause of Severe Acute Respiratory Infection (SARI) in children, with high genotypic diversity in different regions. However, RV type diversity remains unknown in several regions of the world. In this study, the genetic variability of the frequently circulating RV types in Northern Tunisia was investigated, using phylogenetic and phylogeographic analyses with a specific focus on the most frequent RV types: RV-A101 and RV-C45. This study concerned 13 RV types frequently circulating in Northern Tunisia. They were obtained from respiratory samples collected in 271 pediatric SARI cases, between September 2015 and November 2017. A total of 37 RV VP4-VP2 sequences, selected among a total of 49 generated sequences, was compared to 359 sequences from different regions of the world. Evolutionary analysis of RV-A101 and RV-C45 showed high genetic relationship between different Tunisian strains and Malaysian strains. RV-A101 and C45 progenitor viruses' dates were estimated in 1981 and 1995, respectively. Since the early 2000s, the two types had a wide spread throughout the world. Phylogenetic analyses of other frequently circulating strains showed significant homology of Tunisian strains from the same epidemic period, in contrast with earlier strains. The genetic relatedness of RV-A101 and RV-C45 might result from an introduction of viruses from different clades followed by local dissemination rather than a local persistence of an endemic clades along seasons. International traffic may play a key role in the spread of RV-A101, RV-C45, and other RVs.Sondes Haddad-BoubakerCherif Ben HamdaKais GhediraKhaoula MeftehAida BouafsounIlhem Boutiba-Ben BoubakerAmin SlimKhaled MenifHenda TrikiMohamed Ali Ben Hadj KacemHanen SmaouiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259859 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sondes Haddad-Boubaker Cherif Ben Hamda Kais Ghedira Khaoula Mefteh Aida Bouafsoun Ilhem Boutiba-Ben Boubaker Amin Slim Khaled Menif Henda Triki Mohamed Ali Ben Hadj Kacem Hanen Smaoui Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
description	Rhinoviruses (RV) are a major cause of Severe Acute Respiratory Infection (SARI) in children, with high genotypic diversity in different regions. However, RV type diversity remains unknown in several regions of the world. In this study, the genetic variability of the frequently circulating RV types in Northern Tunisia was investigated, using phylogenetic and phylogeographic analyses with a specific focus on the most frequent RV types: RV-A101 and RV-C45. This study concerned 13 RV types frequently circulating in Northern Tunisia. They were obtained from respiratory samples collected in 271 pediatric SARI cases, between September 2015 and November 2017. A total of 37 RV VP4-VP2 sequences, selected among a total of 49 generated sequences, was compared to 359 sequences from different regions of the world. Evolutionary analysis of RV-A101 and RV-C45 showed high genetic relationship between different Tunisian strains and Malaysian strains. RV-A101 and C45 progenitor viruses' dates were estimated in 1981 and 1995, respectively. Since the early 2000s, the two types had a wide spread throughout the world. Phylogenetic analyses of other frequently circulating strains showed significant homology of Tunisian strains from the same epidemic period, in contrast with earlier strains. The genetic relatedness of RV-A101 and RV-C45 might result from an introduction of viruses from different clades followed by local dissemination rather than a local persistence of an endemic clades along seasons. International traffic may play a key role in the spread of RV-A101, RV-C45, and other RVs.
format	article
author	Sondes Haddad-Boubaker Cherif Ben Hamda Kais Ghedira Khaoula Mefteh Aida Bouafsoun Ilhem Boutiba-Ben Boubaker Amin Slim Khaled Menif Henda Triki Mohamed Ali Ben Hadj Kacem Hanen Smaoui
author_facet	Sondes Haddad-Boubaker Cherif Ben Hamda Kais Ghedira Khaoula Mefteh Aida Bouafsoun Ilhem Boutiba-Ben Boubaker Amin Slim Khaled Menif Henda Triki Mohamed Ali Ben Hadj Kacem Hanen Smaoui
author_sort	Sondes Haddad-Boubaker
title	Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
title_short	Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
title_full	Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
title_fullStr	Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
title_full_unstemmed	Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.
title_sort	phylogeography and phylogeny of rhinoviruses collected from severe acute respiratory infection (sari) cases over successive epidemic periods in tunisia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/04583985d59245249057b32756a607a4
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Phylogeography and phylogeny of Rhinoviruses collected from Severe Acute Respiratory Infection (SARI) cases over successive epidemic periods in Tunisia.

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